Association between Serum Atypical Fibroblast Growth Factors 21 and 19 and Pediatric Nonalcoholic Fatty Liver Disease.
Association between Serum Atypical Fibroblast Growth Factors 21 and 19 and Pediatric Nonalcoholic Fatty Liver Disease.
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DOI：
10.1371/journal.pone.0067160
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Nobili V
中科院分区：
文献类型：
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作者：
Alisi A;Ceccarelli S;Panera N;Prono F;Petrini S;De Stefanis C;Pezzullo M;Tozzi A;Villani A;Bedogni G;Nobili V
非典型成纤维细胞生长因子（FGF） 21和19通过Klotho辅助受体在能量代谢中起核心作用。关于FGF21和FGF19与人类非酒精性脂肪性肝病（NAFLD）的关系，目前有相互矛盾的发现。我们研究了血清FGF21、FGF19和肝脏Klotho辅助受体与非酒精性脂肪性肝炎（NASH）和NAFLD儿童纤维化的关系。对84例经活检证实的NAFLD患儿和23例对照组进行血清FGF21和FGF19检测。在7例正常对照组、9例NASH患者（NASH+）和11例非NASH患者（NASH -）中检测肝脏中Klotho辅助受体的表达。FGF21和FGF19从CTRL组（中位数FGF21 = 196 pg/mL；中位数FGF19 = 201 pg/mL）到NASH -组（FGF21 = 89 pg/mL; FGF19 = 81 pg/mL）到NASH+组（FGF21 = 54 pg/mL; FGF19 = 41 pg/mL）呈下降趋势（所有比较p<0.001），并且与NAFLD患儿NASH和纤维化的概率呈负相关。肝脏Klotho共受体的表达与NASH呈负相关（R2 = 0.87, p<0.0001），与血清FGF21 （R2 = 0.57, p<0.0001）和FGF19 （R2 = 0.67, p<0.0001）直接相关。总之，血清FGF19、FGF21和肝脏Klotho表达与NAFLD儿童肝损害呈负相关，这些发现可能对理解NAFLD进展机制具有重要意义。
Atypical fibroblast growth factors (FGF) 21 and 19 play a central role in energy metabolism through the mediation of Klotho coreceptor. Contradictory findings are available about the association of FGF21 and FGF19 with nonalcoholic fatty liver disease (NAFLD) in humans. We investigated the association of serum FGF21, FGF19 and liver Klotho coreceptor with non-alcoholic steatohepatitis (NASH) and fibrosis in children with NAFLD. Serum FGF21 and FGF19 were measured in 84 children with biopsy-proven NAFLD and 23 controls (CTRL). The hepatic expression of Klotho coreceptor was measured in 7 CTRL, 9 patients with NASH (NASH+) and 11 patients without NASH (NASH−). FGF21 and FGF19 showed a tendency to decrease from CTRL (median FGF21 = 196 pg/mL; median FGF19 = 201 pg/mL) to NASH− (FGF21 = 89 pg/mL; FGF19 = 81 pg/mL) to NASH+ patients (FGF21 = 54 pg/mL; FGF19 = 41 pg/mL) (p<0.001 for all comparisons) and were inversely associated with the probability of NASH and fibrosis in children with NAFLD. The hepatic expression of Klotho coreceptor was inversely associated with NASH (R2 = 0.87, p<0.0001) and directly associated with serum FGF21 (R2 = 0.57, p<0.0001) and FGF19 (R2 = 0.67, p<0.0001). In conclusion, serum FGF19 and FGF21 and hepatic Klotho expression are inversely associated with hepatic damage in children with NAFLD and these findings may have important implications for understanding the mechanisms of NAFLD progression.
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影响因子：
3.7
作者：
Latasa MU;Salis F;Urtasun R;Garcia-Irigoyen O;Elizalde M;Uriarte I;Santamaria M;Feo F;Pascale RM;Prieto J;Berasain C;Avila MA
通讯作者：
Avila MA
影响因子：
7.1
作者：
Kliewer, Steven A.;Mangelsdorf, David J.
通讯作者：
Mangelsdorf, David J.
影响因子：
3.6
作者：
Itoh, Nobuyuki
通讯作者：
Itoh, Nobuyuki
影响因子：
4.7
作者：
Cacciari, E;Milani, S;Vanelli, M
通讯作者：
Vanelli, M
DOI：
10.1007/978-1-4614-0887-1_7
发表时间：
2012-01-01
期刊：
ENDOCRINE FGFS AND KLOTHOS
影响因子：
--
作者：
Huang, Chou-Long
通讯作者：
Huang, Chou-Long