Interventions to improve adherence and persistence with osteoporosis medications: a systematic literature review.
Interventions to improve adherence and persistence with osteoporosis medications: a systematic literature review.
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DOI：
10.1007/s00198-009-0976-0
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发表时间：
2009-12
影响因子：
4
通讯作者：
Solomon, D. H.
中科院分区：
文献类型：
--
作者：
Gleeson, T.;Iversen, M. D.;Avorn, J.;Brookhart, A. M.;Katz, J. N.;Losina, E.;May, F.;Patrick, A. R.;Shrank, W. H.;Solomon, D. H.
关键词：
骨质疏松症药物的依从性和持久性较差。我们对改善骨质疏松症药物依从性和持久性的干预措施进行了系统的文献综述。7项研究符合资格要求，并被纳入审查。很少干预措施是有效的，没有明确的趋势，成功的干预技术被确定。然而，患者和卫生专业人员之间的定期随访互动似乎是有益的。骨质疏松症药物治疗的依从性和持久性不理想。我们的目标是检查已发表的干预措施的设计和有效性，以提高依从性和持久性。我们检索了医学文献数据库中1990年1月至2008年7月期间发表的英文论文。我们选择了描述干预措施的论文，并提供了对照组和干预组的结果。我们评估了每项研究的设计和方法，包括随机化、设盲和脱落报告。我们总结了每个试验的结果并计算了效应量。7项研究符合资格要求，并被纳入审查。7项研究中有5项提供了依从性数据。在这5项研究中，3项显示干预组的依从性有统计学显著性改善（p≤0.05），效应量为0.17至0.58。7项研究中有5项提供了持久性数据。在这五个中，一个报告了干预组在持久性方面的统计学显着改善，效应量为0.36。很少有干预措施是有效的，在这个小样本的研究中，没有明确的趋势，成功的干预技术。然而，患者和卫生专业人员之间的定期随访互动似乎是有益的。
Adherence and persistence with osteoporosis medications are poor. We conducted a systematic literature review of interventions to improve adherence and persistence with osteoporosis medications. Seven studies met eligibility requirements and were included in the review. Few interventions were efficacious, and no clear trends regarding successful intervention techniques were identified. However, periodic follow-up interaction between patients and health professionals appeared to be beneficial. Adherence and persistence with pharmacologic therapy for osteoporosis are suboptimal. Our goal was to examine the design and efficacy of published interventions to improve adherence and persistence. We searched medical literature databases for English-language papers published between January 1990 and July 2008. We selected papers that described interventions and provided results for control and intervention subjects. We assessed the design and methods of each study, including randomization, blinding, and reporting of drop-outs. We summarized the results and calculated effect sizes for each trial. Seven studies met eligibility requirements and were included in the review. Five of the seven studies provided adherence data. Of those five studies, three showed a statistically significant (p≤0.05) improvement in adherence by the intervention group, with effect sizes from 0.17 to 0.58. Five of the seven studies provided persistence data. Of those five, one reported statistically significant improvement in persistence by the intervention group, with an effect size of 0.36. Few interventions were efficacious, and no clear trends regarding successful intervention techniques were identified in this small sample of studies. However, periodic follow-up interaction between patients and health professionals appeared to be beneficial.
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影响因子：
5.8
作者：
Delmas, Pierre D.;Vrijens, Bernard;Watts, Nelson B.
通讯作者：
Watts, Nelson B.
影响因子：
6.2
作者：
Burge, Russel;Dawson-Hughes, Bess;Tosteson, Anna
通讯作者：
Tosteson, Anna
影响因子：
4
作者：
Cuddihy, MT;Amadio, PC;Melton, LJ
通讯作者：
Melton, LJ
影响因子：
4
作者：
Majumdar, S. R.;Johnson, J. A.;Rowe, B. H.
通讯作者：
Rowe, B. H.
DOI：
10.1080/09540120701593489
发表时间：
2008-01-01
影响因子：
1.7
作者：
DiIorio, C.;Mccarty, F.;Lundberg, B.
通讯作者：
Lundberg, B.