Case-control study of association of eosinophilic gastrointestinal disorders with Helicobacter pylori infection in Japan.
Case-control study of association of eosinophilic gastrointestinal disorders with Helicobacter pylori infection in Japan.
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DOI：
10.3164/jcbn.13-15
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发表时间：
2013-07
影响因子：
2.4
通讯作者：
Kinoshita Y
中科院分区：
文献类型：
--
作者：
Furuta K;Adachi K;Aimi M;Ishimura N;Sato S;Ishihara S;Kinoshita Y
最近的研究表明，幽门螺杆菌感染的减少可能是变态反应性疾病的易感性。然而，有关嗜酸性胃肠道疾病(EGID)，尤其是嗜酸性胃肠炎(EGE)与幽门螺杆菌感染的关系的报道很少。我们调查了幽门螺杆菌感染对日本患者EGID的可能影响。我们进行了一项病例对照研究，以调查EGIDs患者中幽门螺杆菌感染的患病率。18例嗜酸性食管炎(EoE)和22例EGE入选。对于每个患者，从2010年4月至2011年12月在岛根健康科学研究所接受体检的人群中随机选择3名年龄和性别匹配的正常对照组(n=1120)。EoE和EGE患者的平均年龄分别为50.9±0.17岁和49.2±0.20岁。男性在EoE组中更常见，而在EGE方面没有显著的性别差异。在EoE患者中，22.3%的患者感染了幽门螺杆菌，而年龄和性别匹配的正常对照组中，这一比例为55.5%。EoE患者感染幽门螺杆菌的优势比为0.22(p<；0.05)。此外，22.7%的EGE患者和48.5%的匹配对照组感染了Hp，EGE患者感染Hp的优势比为0.31(p<；0.05)。总而言之，与正常对照组相比，日本EGE和EoE患者的幽门螺杆菌感染率显著降低。
Recent studies have suggested that decrease in Helicobacter pylori infection may predispose to allergic diseases. However, there are few reports of the relationships of eosinophilic gastrointestinal disorders (EGIDs), especially eosinophilic gastroenteritis (EGE), with H. pylori infection. We investigated the possible influence of H. pylori infection on EGIDs in Japanese patients. We performed a case-control study to investigate the prevalence of H. pylori infection in patients with EGIDs. Eighteen with eosinophilic esophagitis (EoE) and 22 with EGE were enrolled. For each patient, 3 age- and gender-matched normal controls (n = 120) were randomly selected from a population who received a medical check-up between April 2010 and December 2011 at the Shimane Institute of Health Science. The mean ages of the EoE and EGE patients were 50.9 ± 17 and 49.2 ± 20 years, respectively. Males were more frequently seen in the EoE group, while there was no significant gender difference in regard to EGE. Of the patients with EoE, 22.3% were infected with H. pylori, as compared to 55.5% of their age- and sex-matched normal controls. The odds ratio for EoE patients to have an H. pylori infection was 0.22 (p<0.05). In addition, 22.7% of the patients with EGE and 48.5% of their matched controls were infected with H. pylori, with odds ratio for EGE patients to have an H. pylori infection shown to be 0.31 (p<0.05). In conclusion, the prevalence of H. pylori infection was significantly lower in EGE and EoE patients in Japan as compared to normal control subjects.
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影响因子：
4.6
作者：
Okada, H.;Kuhn, C.;Bach, J. -F.
通讯作者：
Bach, J. -F.
影响因子：
2.5
作者：
Liacouras, CA
通讯作者：
Liacouras, CA
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6.3
作者：
Fujishiro, Hirofumi;Amano, Yuji;Kinoshita, Yoshikazu
通讯作者：
Kinoshita, Yoshikazu
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作者：
Amedei, A;Cappon, A;de Bernard, M
通讯作者：
de Bernard, M
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作者：
Kapel, Robert C.;Miller, Jocelyne K.;Katzka, David A.
通讯作者：
Katzka, David A.