Antiviral activity of a zymolytic grain based extract on human immunodeficiency virus type 1 in vitro.
Antiviral activity of a zymolytic grain based extract on human immunodeficiency virus type 1 in vitro.
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DOI：
10.1155/2015/642327
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Yu XH
中科院分区：
文献类型：
--
作者：
Wang C;Liu D;Guo XH;Yu B;Wu H;Zhang HH;Wu JX;Jiang CL;Kong W;Yu XH
越来越多的证据表明，谷物在预防疾病方面可能发挥着超越简单提供能量和营养的作用。据报道，谷物中含有的一些成分对病毒和细菌感染发挥作用，并预防各种癌症。然而，到目前为止，几乎没有任何干预研究调查了谷物或基于谷物的提取物对抑制HIV-1感染的影响。本研究通过体外和大鼠体内试验检测了一种发酵谷物提取物（ZGE）的抗病毒作用，并对其抗病毒机制进行了初步探讨。结果表明，ZGE在体外对HIV-1感染有抑制作用，且细胞毒作用较低。机理研究表明，该功能性食品可能作用于负责细胞结合的病毒表面结构蛋白gp 120，以及病毒的后附着阶段。模型大鼠灌胃给予该食品后，其血清在一定时间内表现出抗HIV-1感染的能力。这些发现为ZGE在控制病毒载量方面的应用提供了有价值的见解，这可能有助于未来的抗HIV治疗，减少不良反应。
Increasing evidence shows that grains may play a role in disease prevention beyond the simple provision of energy and nutrients. It has been reported that some components contained in grains exert their functional effects on viral and bacterial infections and protect against various cancers. However, until now, hardly any intervention studies have investigated the effects of grains or grain based extracts on the inhibition of HIV-1 infection. In this study, the antiviral function of a zymolytic grain based extract (ZGE) was detected in vitro and in rats, and the antiviral mechanism was investigated. Results showed that ZGE had an inhibition effect on HIV-1 infection in vitro with low cytotoxic effects. The study of the mechanism demonstrated that this functional food possibly acted on the viral surface structure protein gp120 which is responsible for cell binding, as well as on the postattachment stage of the virus. The sera of model rats administrated with this food by gavage presented anti-infection abilities against HIV-1 in vitro during a serum concentration associated period of time. These findings provide valuable insights into the application of ZGE on the control of viral load, which may contribute to future anti-HIV treatment with less adverse effects.
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影响因子：
4.8
作者：
Henderson HI;Hope TJ
通讯作者：
Hope TJ
影响因子：
7.2
作者：
Kaup, Rebecca M.;Khayyal, Mohamed T.;Verspohl, Eugen J.
通讯作者：
Verspohl, Eugen J.
DOI：
10.1097/00042560-199604150-00001
发表时间：
1996-01-01
期刊：
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY
影响因子：
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作者：
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通讯作者：
Meijer, DKF
DOI：
10.1016/j.bbrc.2012.06.097
发表时间：
2012-07-27
影响因子：
3.1
作者：
Li, Xiaoguang;Qian, Hua;Kodama, Eiichi N.
通讯作者：
Kodama, Eiichi N.
影响因子：
5.4
作者：
Dennison, S. Moses;Stewart, Shelley M.;Alam, S. Munir
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Alam, S. Munir