Rational consideration of Akkermansia muciniphila targeting intestinal health: advantages and challenges.
Rational consideration of Akkermansia muciniphila targeting intestinal health: advantages and challenges.
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理性思考针对肠道健康的Akkermansia muciniphila：优势与挑战
DOI：
10.1038/s41522-022-00338-4
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发表时间：
2022-10-17
影响因子：
9.2
通讯作者：
Wright, Andre-Denis G.
中科院分区：
文献类型：
--
作者：
Luo, Yuheng;Lan, Cong;Li, Hua;Ouyang, Qingyuan;Kong, Fanli;Wu, Aimin;Ren, Zhihua;Tian, Gang;Cai, Jingyi;Yu, Bing;He, Jun;Wright, Andre-Denis G.
嗜粘菌（Akkermansia muciniphila）是一种众所周知的降解黏液蛋白的细菌，已被证明与其宿主代谢疾病密切相关，是一种很有前景的下一代益生菌（NGPs）。然而，嗜粘杆菌在宿主肠道健康中的作用仍不明确。本文就嗜粘杆菌在人胃肠道（GIT）的特点、分布及定植进行综述和讨论。我们建议应谨慎考虑嗜粘杆菌作为寿命、肠道疾病诊断和预后或肠道健康的生物标志物的应用。精确的饮食调节可以通过改变嗜粘杆菌的丰度来调节肠道疾病的治疗。虽然已经发现嗜粘杆菌及其成分在肠道炎症中的有益作用，但在具有特定肠道菌群、特定基因型和结直肠癌的非生小鼠中，或在感染特定病原体的动物模型中，嗜粘杆菌可能与肠道疾病的发生和发展有关。基因组分析，强调菌株水平的系统发育差异，表明在实际应用之前对每个菌株进行清晰的描述和讨论是至关重要的。我们的研究为嗜粘液芽孢杆菌的精确应用提供了必要的见解。
As one of the promising next-generation probiotics (NGPs), Akkermansia muciniphila, a well-known mucin-degrading bacterium, has been proven to be closely related to the metabolic diseases of its human host. However, the role of A. muciniphila in the host’s intestinal health remains ambiguous. Here, we comprehensively summarize and discuss the characteristics, the distribution, and the colonization of A. muciniphila in the human gastrointestinal tract (GIT). We propose that the application of A. muciniphila as a biomarker for longevity, for diagnostics and prognostics of intestinal diseases, or for intestinal health should be cautiously considered. Precise dietary regulation can mediate the treatment of intestinal diseases by altering the abundance of A. muciniphila. Although the beneficial role of A. muciniphila and its component in intestinal inflammation has been discovered, in gnotobiotic mice with specific gut microbiota, certain genotype, and colorectal cancer, or in animal models infected with a specific pathogen, A. muciniphila may be related to the occurrence and development of intestinal diseases. Genomic analysis, emphasizing the strain-level phylogenetic differences of A. muciniphila, indicates that a clear description and discussion of each strain is critical before its practical application. Our review provides much needed insight for the precise application of A. muciniphila.
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DOI：
10.1038/nrrheum.2012.58
发表时间：
2012-05-01
期刊：
Nature reviews. Rheumatology
影响因子：
--
作者：
通讯作者：
--
影响因子：
32.4
作者：
Bunker JJ;Flynn TM;Koval JC;Shaw DG;Meisel M;McDonald BD;Ishizuka IE;Dent AL;Wilson PC;Jabri B;Antonopoulos DA;Bendelac A
通讯作者：
Bendelac A
影响因子：
24.5
作者：
Asnicar F;Leeming ER;Dimidi E;Mazidi M;Franks PW;Al Khatib H;Valdes AM;Davies R;Bakker E;Francis L;Chan A;Gibson R;Hadjigeorgiou G;Wolf J;Spector TD;Segata N;Berry SE
通讯作者：
Berry SE
影响因子：
12.8
作者：
Chelakkot C;Choi Y;Kim DK;Park HT;Ghim J;Kwon Y;Jeon J;Kim MS;Jee YK;Gho YS;Park HS;Kim YK;Ryu SH
通讯作者：
Ryu SH
影响因子：
82.9
作者：
Barcena, Clea;Valdes-Mas, Rafael;Lopez-Otin, Carlos
通讯作者：
Lopez-Otin, Carlos