PBmice: an integrated database system of piggyBac (PB) insertional mutations and their characterizations in mice.
PBmice: an integrated database system of piggyBac (PB) insertional mutations and their characterizations in mice.
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PBMICE：PIGGYBAC（PB）插入突变的集成数据库系统及其在小鼠中的表征。
DOI：
10.1093/nar/gkm790
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发表时间：
2008-01
影响因子：
14.9
通讯作者：
Zhong, Yang
中科院分区：
文献类型：
--
作者：
Sun, Ling V.;Jin, Ke;Liu, Yiming;Yang, Wenwei;Xie, Xing;Ye, Lin;Wang, Li;Zhu, Lin;Ding, Sheng;Su, Yi;Zhou, Jie;Han, Min;Zhuang, Yuan;Xu, Tian;Wu, Xiaohui;Gu, Ning;Zhong, Yang
DNA转座子piggyBac（PB）是新近建立的一种用于小鼠大规模诱变的诱变剂。我们设计并实现了一个集成的数据库系统PBmice（PB Mutagenesis Information Center），用于存储、检索和显示小鼠基因组中PB插入（PB insertions，BUTTs）的信息。该系统以BRTs为中心，其信息包括它们的基因组位置和侧翼基因组序列、命中基因的表达水平以及如果使用捕获载体的话被捕获基因的表达模式。它还将与BMPT相关的小鼠表型数据存档，并允许用户对与特定或一组BMPT相关的基因型和表型信息进行快速和高级搜索。基于序列的信息可以与其他基因组数据库交叉引用，如在PB小鼠中使用的Ensembl、BLAST和GBrowse工具提供增强的搜索和显示与BPTT相关的额外信息。还可以通过用户友好的界面查看PB插入序列的总数和基因组分布以及每个PB插入序列的可用性。PBmice可在http://www.idmshanghai.cn/PBmice或http://www.scbit.org/PBmice/上免费获得。
DNA transposon piggyBac (PB) is a newly established mutagen for large-scale mutagenesis in mice. We have designed and implemented an integrated database system called PBmice (PB Mutagenesis Information CEnter) for storing, retrieving and displaying the information derived from PB insertions (INSERTs) in the mouse genome. This system is centered on INSERTs with information including their genomic locations and flanking genomic sequences, the expression levels of the hit genes, and the expression patterns of the trapped genes if a trapping vector was used. It also archives mouse phenotyping data linked to INSERTs, and allows users to conduct quick and advanced searches for genotypic and phenotypic information relevant to a particular or a set of INSERT(s). Sequence-based information can be cross-referenced with other genomic databases such as Ensembl, BLAST and GBrowse tools used in PBmice offer enhanced search and display for additional information relevant to INSERTs. The total number and genomic distribution of PB INSERTs, as well as the availability of each PB insertional LINE can also be viewed with user-friendly interfaces. PBmice is freely available at http://www.idmshanghai.cn/PBmice or http://www.scbit.org/PBmice/.
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影响因子：
56.9
作者：
Mochizuki, T;Wu, GQ;Somlo, S
通讯作者：
Somlo, S
DOI：
10.1101/sqb.1997.062.01.052
发表时间：
1997-01-01
期刊：
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY
影响因子：
--
作者：
Amsterdam, A;Yoon, C;Hopkins, N
通讯作者：
Hopkins, N
影响因子：
56.9
作者：
COOLEY, L;KELLEY, R;SPRADLING, A
通讯作者：
SPRADLING, A
影响因子：
6.9
作者：
Koiwa, H;Bressan, RA;Hasegawa, PM
通讯作者：
Hasegawa, PM
DOI：
10.1073/pnas.0504679102
发表时间：
2005-11-08
影响因子：
11.1
作者：
Balu, B;Shoue, DA;Adams, JH
通讯作者：
Adams, JH