Corticospinal excitability enhancement with simultaneous transcranial near-infrared stimulation and anodal direct current stimulation of motor cortex
Corticospinal excitability enhancement with simultaneous transcranial near-infrared stimulation and anodal direct current stimulation of motor cortex
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同时经颅近红外刺激和运动皮层阳极直流电刺激增强皮质脊髓兴奋性
DOI：
10.1016/j.clinph.2021.01.020
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发表时间：
2021-02
影响因子：
4.7
通讯作者：
Wang Yuping
中科院分区：
文献类型：
--
作者：
Song Penghui;Li Siran;Hao Wensi;Wei Min;Liu Jianghong;Lin Hua;Hu Shimin;Dai Xiaona;Wang Jing;Wang Rong;Wang Yuping
目的无创脑刺激 (NIBS) 通过调节神经可塑性和皮质兴奋性，有益于许多神经和精神疾病。然而，最近的研究表明，单一类型的 NIBS，如经颅直流电刺激 (tDCS)，由于其效应较小，不具有有意义的临床治疗反应。经颅近红外刺激 (tNIRS) 是 NIBS 的一种新型形式。 tNIRS 和 tDCS 均通过调节皮质兴奋性来实现治疗效果，但机制不同。我们假设同时 tNIRS 和 tDCS 优于单一刺激，从而导致更大的皮质兴奋性。方法 16 名健康受试者参加了一项双盲、假对照、交叉设计的研究。运动诱发电位（MEP）用于测量运动皮层兴奋性。计算并比较假手术条件、tDCS刺激条件、tNIRS条件以及同时tNIRS和阳极tDCS条件下MEP的变化。结果单独DCS和单独tNIRS刺激后均引起较高的MEP，而同时tNIRS和tDCS条件下的MEP幅度显着高于单独tNIRS或单独tDCS。这种增强作用在刺激后持续至少 30 分钟，表明同步 820 nm tNIRS 与 2 mA 阳极 tDCS 对皮质可塑性具有协同作用。结论同时应用 tNIRS 与 tDCS 会产生更强的皮质兴奋性效应。意义同步 tNIRS 和 tDCS 是一种有前景的技术，具有作为治疗、神经增强或治疗手段的令人兴奋的潜力。神经保护。
ObjectivesNon-invasive brain stimulation (NIBS) is beneficial to many neurological and psychiatric disorders by modulating neuroplasticity and cortical excitability. However, recent studies evidence that single type of NIBS such as transcranial direct current stimulation (tDCS) does not have meaningful clinical therapeutic responses due to their small effect size. Transcranial near-infrared stimulation (tNIRS) is a novel form of NIBS. Both tNIRS and tDCS implement its therapeutic effects by modulating cortical excitability but with different mechanisms. We hypothesized that simultaneous tNIRS and tDCS is superior to single stimulation, leading to a greater cortical excitability.MethodsSixteen healthy subjects participated in a double-blind, sham-controlled, cross-over designed study. Motor evoked potentials (MEPs) were used to measure motor cortex excitability. The changes of MEP were calculated and compared in the sham condition, tDCS stimulation condition, tNIRS condition and the simultaneous tNIRS and anodal tDCS condition.ResultstDCS alone and tNIRS alone both elicited higher MEP after stimulation, while the MEP amplitude in the simultaneous tNIRS and tDCS condition was significantly higher than either tNIRS alone or tDCS alone. The enhancement lasted up to at least 30 minutes after stimulation, indicating simultaneous 820 nm tNIRS with 2 mA anodal tDCS have a synergistic effect on cortical plasticity.ConclusionsSimultaneous application of tNIRS with tDCS produces a stronger cortical excitability effect.SignificanceThe simultaneous tNIRS and tDCS is a promising technology with exciting potential as a means of treatment, neuro-enhancement, or neuro-protection.
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经颅近红外刺激可能会增加人类皮层兴奋性
影响因子：
3.8
作者：
Song Penghui;Han Tao;Lin Hua;Li Siran;Huang Qian;Dai Xiaona;Wang Rong;Wang Yuping
通讯作者：
Wang Yuping
影响因子：
2.9
作者：
Rosen DS;Erickson B;Kim YE;Mirman D;Hamilton RH;Kounios J
通讯作者：
Kounios J
影响因子：
25.8
作者：
B. Sampaio-Júnior;G. Tortella;Lucas Borrione;A. Moffa;R. Machado-Vieira;Eric Cretaz;Adriano Fernandes da Silva;R. Fráguas;L. V. Aparicio;Izio Klein;B. Lafer;S. Goerigk;I. Benseñor;P. Lotufo;W. Gattaz;A. Brunoni
通讯作者：
B. Sampaio-Júnior;G. Tortella;Lucas Borrione;A. Moffa;R. Machado-Vieira;Eric Cretaz;Adriano Fernandes da Silva;R. Fráguas;L. V. Aparicio;Izio Klein;B. Lafer;S. Goerigk;I. Benseñor;P. Lotufo;W. Gattaz;A. Brunoni
影响因子：
7.7
作者：
Schabrun, Siobhan M.;Chipchase, Lucinda S.;Hodges, Paul W.
通讯作者：
Hodges, Paul W.
影响因子：
2.9
作者：
I. Szundi;Guang-Ling Liao;Ó. Einarsdóttir
通讯作者：
I. Szundi;Guang-Ling Liao;Ó. Einarsdóttir