Akkermansia muciniphila, a New Generation of Beneficial Microbiota in Modulating Obesity: A Systematic Review.
Akkermansia muciniphila, a New Generation of Beneficial Microbiota in Modulating Obesity: A Systematic Review.
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DOI：
10.3390/microorganisms9051098
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发表时间：
2021-05-20
期刊：
影响因子：
4.5
通讯作者：
Altamimi M
中科院分区：
文献类型：
--
作者：
Abuqwider JN;Mauriello G;Altamimi M
肥胖是一种复杂的综合征，被认为是许多慢性病的最终途径。使用Akkermansia粘液补充剂策略的研究已被证明对预防和治疗肥胖症和其他代谢紊乱有效。虽然有研究支持这一策略的保护作用，但对预防人类肥胖的效果尚不清楚，还需要更多的研究。本研究的目的是研究粘液曲霉对肥胖的调节作用。这一系统的综述是从过去10年内发表的文章中产生的。所有的文章都是英文的，包括动物题材。这篇综述依赖于谷歌学者、Pub Med、Web of Science和Medline的搜索引擎，并检索了以下关键词：粘液杆菌、下一代益生菌、新一代益生菌、肥胖症、脂肪量、体脂和脂类。搜索发现了804篇带有相关关键词的文章。排除无关文献后，根据标准选择10篇研究。这些研究是随机对照试验，表明粘液曲霉通过调节新陈代谢和能量止血以及改善胰岛素敏感性和葡萄糖止血来调节肥胖。此外，研究表明，这种微生物通过不同的机制增强低度炎症。
Obesity is a complex syndrome and is recognized as the ultimate pathway of many chronic diseases. Studies using Akkermansia muciniphila supplementation strategy have proved to be effective for the prevention and treatment of obesity and other metabolic disorders. Although there are studies that support the protective effect of this strategy, the effects on the prevention of obesity on humans are not clear yet and need more investigation. The aim of this study is to investigate the effect of A. muciniphila administration on modulating obesity. This systematic review was generated from articles published within the last 10 years. All articles were in English and included animal subjects. The review relied on the search engines Google Scholar, Pub Med, Web of Science and Medline using the following keywords: A. muciniphila, next-generation probiotic, new-generation probiotic, obesity, fat mass, body fat and lipid profile. The search has revealed 804 articles with relevant key words. After the exclusion of irrelevant articles, 10 studies were selected based on the criteria. These studies were randomized controlled trials that have shown that A. muciniphila modulates obesity by regulating metabolism and energy hemostasis and improving insulin sensitivity and glucose hemostasis. In addition, studies showed this microorganism enhances low grade inflammation by different mechanisms.
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影响因子：
4.5
作者：
Corb Aron RA;Abid A;Vesa CM;Nechifor AC;Behl T;Ghitea TC;Munteanu MA;Fratila O;Andronie-Cioara FL;Toma MM;Bungau S
通讯作者：
Bungau S
影响因子：
5.2
作者：
Cani PD;de Vos WM
通讯作者：
de Vos WM
DOI：
10.1038/oby.2004.140
发表时间：
2004-07-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Erem, C;Arslan, C;Telatar, M
通讯作者：
Telatar, M
DOI：
10.1073/pnas.1219451110
发表时间：
2013-05-28
影响因子：
11.1
作者：
Everard, Amandine;Belzer, Clara;Cani, Patrice D.
通讯作者：
Cani, Patrice D.
影响因子：
6.3
作者：
Downs, SH;Black, N
通讯作者：
Black, N