μ-Opioid activation in the midbrain during migraine allodynia - brief report II.
μ-Opioid activation in the midbrain during migraine allodynia - brief report II.
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DOI：
10.1002/acn3.66
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发表时间：
2014-06
影响因子：
5.3
通讯作者：
DaSilva, Alexandre F.
中科院分区：
文献类型：
--
作者：
Nascimento, Thiago D.;DosSantos, Marcos F.;Lucas, Sarah;van Holsbeeck, Hendrik;DeBoer, Misty;Maslowski, Eric;Love, Tiffany;Martikainen, Ilkka K.;Koeppe, Robert A.;Smith, Yolanda R.;Zubieta, Jon-Kar;DaSilva, Alexandre F.
我们在体内研究了自发性偏头痛时中枢μ-阿片系统的异常性疼痛反应，随后对三叉神经眼区进行持续痛阈挑战。使用正电子发射断层扫描（PET）和选择性μ-阿片受体（μOR）放射性示踪剂[11 C]卡芬太尼在发作期和发作间期对6名偏头痛患者进行扫描。在两个单独周期的卵泡中期-晚期扫描雌性。患者在热激发期间表现出发作性三叉神经异常性疼痛，这与中脑中的μOR激活同时呈正相关，从红核延伸到中脑导水管周围灰质腹外侧。这些发现首次在体内证明偏头痛患者的大脑中对异常性疼痛的反应是高μOR激活。
We investigated in vivo the allodynic response of the central μ-opioid system during spontaneous migraine headaches, following a sustained pain threshold challenge on the trigeminal ophthalmic region. Six migraineurs were scanned during the ictal and interictal phases using positron emission tomography (PET) with the selective μ-opioid receptor (μOR) radiotracer [11C]carfentanil. Females were scanned during the mid-late follicular phase of two separate cycles. Patients showed ictal trigeminal allodynia during the thermal challenge that was concurrent and positively correlated with μOR activation in the midbrain, extending from red nucleus to ventrolateral periaqueductal gray matter. These findings demonstrate for the first time in vivo the high μOR activation in the migraineurs' brains in response to their allodynic experience.
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DOI：
10.1111/j.1468-2982.2009.01873.x
发表时间：
2009-12
期刊：
Cephalalgia : an international journal of headache
影响因子：
--
作者：
De Felice M;Porreca F
通讯作者：
Porreca F
影响因子：
5.3
作者：
Stankewitz, Anne;Aderjan, David;May, Arne
通讯作者：
May, Arne
影响因子：
3.1
作者：
Jewett, DM
通讯作者：
Jewett, DM
影响因子：
10.9
作者：
Meyer, C R;Boes, J L;Wahl, R L
通讯作者：
Wahl, R L
影响因子：
5
作者：
TITELER, M;LYON, RA;STRUBLE, RG
通讯作者：
STRUBLE, RG