Neuronal genes for subcutaneous fat thickness in human and pig are identified by local genomic sequencing and combined SNP association study.
Neuronal genes for subcutaneous fat thickness in human and pig are identified by local genomic sequencing and combined SNP association study.
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DOI：
10.1371/journal.pone.0016356
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发表时间：
2011-02-02
期刊：
影响因子：
3.7
通讯作者：
Kim H
中科院分区：
文献类型：
--
作者：
Lee KT;Byun MJ;Kang KS;Park EW;Lee SH;Cho S;Kim H;Kim KW;Lee T;Park JE;Park W;Shin D;Park HS;Jeon JT;Choi BH;Jang GW;Choi SH;Kim DW;Lim D;Park HS;Park MR;Ott J;Schook LB;Kim TH;Kim H
肥胖是一个重大的全球公共卫生问题，会增加患心血管疾病或代谢性疾病的风险。猪代表了一种与人类能量新陈代谢和肥胖相关的特殊生物医学模型。为了找出一种常见肥胖症的致病遗传因素，我们对猪的一个影响脂肪性状的QTL区域进行了18.2Mb的局部基因组从头测序，并对猪的背脂厚度和肌内脂肪含量进行了SNP关联研究。为了将猪与人类肥胖的相关性研究联系起来，我们对8,842名韩国人进行了一项有针对性的全基因组皮下脂肪厚度相关性研究。在人和猪的联合关联研究中，发现了一个显著的SNP，位于一个基因家族中，序列相似性73，A成员(FAM73A)与人肩下皮褶厚度(rs4121165，GC校正p值 = 0.0000175)和猪背脂厚度(ASGA0029495，p值 = 0.000031)相关。我们的联合关联研究还表明，8个神经元基因与皮下脂肪厚度有关：NEGR1、SLC44A5、PDE4B、LPHN2、ELTD1、ST6GALNAC3、ST6GALNAC5和TTLL7。这些结果有力地支持了中枢神经系统在常见肥胖的遗传易感性中的重要作用。
Obesity represents a major global public health problem that increases the risk for cardiovascular or metabolic disease. The pigs represent an exceptional biomedical model related to energy metabolism and obesity in humans. To pinpoint causal genetic factors for a common form of obesity, we conducted local genomic de novo sequencing, 18.2 Mb, of a porcine QTL region affecting fatness traits, and carried out SNP association studies for backfat thickness and intramuscular fat content in pigs. In order to relate the association studies in pigs to human obesity, we performed a targeted genome wide association study for subcutaneous fat thickness in a cohort population of 8,842 Korean individuals. These combined association studies in human and pig revealed a significant SNP located in a gene family with sequence similarity 73, member A (FAM73A) associated with subscapular skin-fold thickness in humans (rs4121165, GC-corrected p-value = 0.0000175) and with backfat thickness in pigs (ASGA0029495, p-value = 0.000031). Our combined association studies also suggest that eight neuronal genes are responsible for subcutaneous fat thickness: NEGR1, SLC44A5, PDE4B, LPHN2, ELTD1, ST6GALNAC3, ST6GALNAC5, and TTLL7. These results provide strong support for a major involvement of the CNS in the genetic predisposition to a common form of obesity.
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DOI：
10.5713/ajas.2002.1178
发表时间：
2002-08-01
期刊：
ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES
影响因子：
--
作者：
Choy, YH;Jeon, GJ;Chung, HW
通讯作者：
Chung, HW
影响因子：
5.8
作者：
Gonzalez, Juan R.;Armengol, Lluis;Moreno, Victor
通讯作者：
Moreno, Victor
影响因子：
64.8
作者：
Kahn, Steven E.;Hull, Rebecca L.;Utzschneider, Kristina M.
通讯作者：
Utzschneider, Kristina M.
DOI：
10.1124/jpet.108.149831
发表时间：
2009-05
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Dahlin A;Royall J;Hohmann JG;Wang J
通讯作者：
Wang J
DOI：
10.1002/ajmg.b.30958
发表时间：
2010-01-01
影响因子：
2.8
作者：
Kahler, Anna K.;Otnaess, Mona K.;Djurovic, Srdjan
通讯作者：
Djurovic, Srdjan