Stress responses from the endoplasmic reticulum in cancer.
Stress responses from the endoplasmic reticulum in cancer.
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DOI：
10.3389/fonc.2015.00093
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发表时间：
2015
影响因子：
4.7
通讯作者：
Nishitoh H
中科院分区：
文献类型：
--
作者：
Kato H;Nishitoh H
内质网（ER）是一种动态的细胞器，对多种细胞功能至关重要。在细胞应激条件下，包括营养缺乏和蛋白质合成失调，未折叠/错误折叠的蛋白质积累在ER腔，导致未折叠蛋白质反应（UPR）的激活。UPR还有助于调节各种细胞内信号传导途径，如钙信号传导和脂质信号传导。最近，作为ER和线粒体之间紧密接触的位点的线粒体相关ER膜（MAM）已被证明作为各种细胞内应激反应的平台，包括凋亡信号传导、炎症信号传导、自噬反应和UPR。有趣的是，在癌症中，这些来自ER的信号通路经常失调，导致癌细胞代谢。因此，来自ER的信号通路可能是各种癌症的新的治疗靶点。在这篇综述中，我们讨论了最近的研究的压力反应的作用，从ER，包括MAM。
The endoplasmic reticulum (ER) is a dynamic organelle that is essential for multiple cellular functions. During cellular stress conditions, including nutrient deprivation and dysregulation of protein synthesis, unfolded/misfolded proteins accumulate in the ER lumen, resulting in activation of the unfolded protein response (UPR). The UPR also contributes to the regulation of various intracellular signaling pathways such as calcium signaling and lipid signaling. More recently, the mitochondria-associated ER membrane (MAM), which is a site of close contact between the ER and mitochondria, has been shown to function as a platform for various intracellular stress responses including apoptotic signaling, inflammatory signaling, the autophagic response, and the UPR. Interestingly, in cancer, these signaling pathways from the ER are often dysregulated, contributing to cancer cell metabolism. Thus, the signaling pathway from the ER may be a novel therapeutic target for various cancers. In this review, we discuss recent research on the roles of stress responses from the ER, including the MAM.
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影响因子：
64.5
作者：
Cárdenas C;Miller RA;Smith I;Bui T;Molgó J;Müller M;Vais H;Cheung KH;Yang J;Parker I;Thompson CB;Birnbaum MJ;Hallows KR;Foskett JK
通讯作者：
Foskett JK
影响因子：
4
作者：
Berridge, MJ
通讯作者：
Berridge, MJ
影响因子：
64.8
作者：
Chen, Xi;Iliopoulos, Dimitrios;Zhang, Qing;Tang, Qianzi;Greenblatt, Matthew B.;Hatziapostolou, Maria;Lim, Elgene;Tam, Wai Leong;Ni, Min;Chen, Yiwen;Mai, Junhua;Shen, Haifa;Hu, Dorothy Z.;Adoro, Stanley;Hu, Bella;Song, Minkyung;Tan, Chen;Landis, Melissa D.;Ferrari, Mauro;Shin, Sandra J.;Brown, Myles;Chang, Jenny C.;Liu, X. Shirley;Glimcher, Laurie H.
通讯作者：
Glimcher, Laurie H.
DOI：
10.1084/jem.20100050
发表时间：
2010-05-10
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Allen IC;TeKippe EM;Woodford RM;Uronis JM;Holl EK;Rogers AB;Herfarth HH;Jobin C;Ting JP
通讯作者：
Ting JP
DOI：
10.1074/jbc.m110.126870
发表时间：
2010-07-16
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Ariyama H;Kono N;Matsuda S;Inoue T;Arai H
通讯作者：
Arai H