Effect of Intravitreal Conbercept Injection on Complications of Pars Plana Vitrectomy in Patients with Proliferative Diabetic Retinopathy.
Effect of Intravitreal Conbercept Injection on Complications of Pars Plana Vitrectomy in Patients with Proliferative Diabetic Retinopathy.
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DOI：
10.3390/jpm13040572
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发表时间：
2023-03-23
影响因子：
--
通讯作者：
Sun, Zilin
中科院分区：
文献类型：
--
作者：
Ding, Yuzhi;Su, Na;Luan, Jie;Ni, Yan;Sun, Zilin
关键词：
背景资料：观察增生性糖尿病视网膜病变（PDR）患者玻璃体切除术（PPV）前玻璃体内注射康柏西普（IVC）对手术并发症的影响。研究方法：选取2019年11月至2020年11月在江苏省人民医院手术的PDR患者共152例，分为两组：术前玻璃体内注射康柏西普+ PPV组（IVC组）124例，单纯PPV组（No-IVC组）28例。所有患者行玻璃体切除术后均采集玻璃体标本，用Luminex法测定VEGF-A含量。评估康柏西普对PDR术中和术后并发症的影响。结果如下：IVC组玻璃体中VEGF含量明显低于无IVC组（64.50 ± 58.40 pg/mL vs.805.17 ± 417.60 pg/mL，p < 0.001）。术后随访中，13/142眼（9.15%）发生术后早期玻璃体积血（VH）。与No-IVC组相比，IVC组中存在VH和纤维血管膜（FVM）或高度复杂性的PDR患者术中出血率较低（p < 0.05）。IVC组术后早期出血率明显低于非IVC组（6.03%vs.23.08%，p < 0.05）。IVC组术中电凝和医源性视网膜裂孔的数量显著低于No-IVC组（p < 0.05）。两组间眼压和NVG数量无显著差异。两组患者术后视力均有不同程度的提高，术后3个月视力最高。结论：PPV术前行IVC可降低玻璃体VEGF-A水平，减少手术并发症。
Background: The effect of intravitreal conbercept (IVC) before pars plana vitrectomy (PPV) on surgical complications in patients with proliferative diabetic retinopathy (PDR) was observed. Methods: A total of 152 patients with PDR operated on in Jiangsu Provincial People’s Hospital from November 2019 to November 2020 were divided into two groups: 124 patients in the preoperative intravitreal conbercept injection + PPV group (IVC group) and 28 patients in the PPV only group (No-IVC group). Vitreous samples were collected in all eyes of patients who underwent vitrectomy, and the content of VEGF-A was measured by Luminex. The effect of conbercept on intraoperative and postoperative complications of PDR was assessed. Results: The content of VEGF in the vitreous of the IVC group was significantly lower than that in the No-IVC group (64.50 ± 58.40 pg/mL vs. 805.17 ± 417.60 pg/mL, p < 0.001). During postoperative follow-up, early postoperative vitreous hemorrhage (VH) occurred in 13 of 142 eyes (9.15%). Compared with the No-IVC group, PDR patients with VH and fibrovascular membrane (FVM) or high complexity in the IVC group had lower intraoperative bleeding rates (p < 0.05). The early postoperative hemorrhage rate in the IVC group was lower than in the No-IVC group (6.03% vs. 23.08%, p < 0.05). The number of intraoperative electrocoagulation and iatrogenic retinal holes in the IVC group was significantly lower than in the No-IVC group (p < 0.05). There were no significant differences in intraocular hypertension and NVG numbers between the two groups. Visual acuity in both groups improved after PPV surgery, reaching the highest level in the 3rd month after the operation. Conclusions: IVC before PPV can reduce the level of VEGF-A in the vitreous body and reduce surgical complications.
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影响因子：
2.7
作者：
Zhang Y;Gao Z;Zhang X;Yuan Z;Ma T;Li G;Gao X
通讯作者：
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影响因子：
2.3
作者：
Gao, Shuang;Lin, Zhongjing;Shen, Xi
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DOI：
10.1097/iae.0000000000000577
发表时间：
2015-09-01
影响因子：
3.3
作者：
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影响因子：
5.1
作者：
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影响因子：
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作者：
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通讯作者：
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