Gut microbiota diversity across ethnicities in the United States.
Gut microbiota diversity across ethnicities in the United States.
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DOI：
10.1371/journal.pbio.2006842
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发表时间：
2018-12
期刊：
影响因子：
9.8
通讯作者：
Bordenstein SR
中科院分区：
文献类型：
--
作者：
Brooks AW;Priya S;Blekhman R;Bordenstein SR
人类肠道微生物群由数百种微生物组成，其组成可能因慢性疾病而异，这些慢性疾病是影响少数民族健康差异的基础。然而，种族对肠道微生物群的影响在很大程度上仍未被探索，并且在研究中缺乏可重复的概括。通过提取两个基于美国的16 S肠道微生物群数据集（包括1，673名个体）中种族与差异之间的关联，我们报告了12个微生物属和家族，这些属和家族可重复地因种族而异。有趣的是，大多数这些微生物类群，包括最可遗传的细菌家族，Christensenellaceae，与遗传相关的类群重叠，并形成由类似的发酵和产甲烷代谢过程连接的共同发生的集群。这些结果表明，肠道微生物群中的特定类群与种族之间存在经常性关联，为检查肠道微生物群的特定成员作为健康差异的介导者提供了假设。了解不同种族之间微生物群的相似性和差异性有可能推进旨在个性化微生物发现和治疗的方法，特别是那些涉及种族健康差异的方法。在这里，我们探讨了美国1,673名健康个体的自我申报种族是否与肠道微生物群组成一致。我们发现四个种族之间的分类组成存在细微但显着的差异，我们在两个研究人群中复制了这些结果。在美国人的肠道微生物群中，至少有12种微生物类群，它们在不同种族之间的丰度可重复地变化。这些分类群往往在丰度和代谢功能方面相互关联，并与先前确定的与人类遗传变异相关的分类群重叠。我们讨论了这些类群在消化和疾病中的作用，并提出了它们如何与种族健康差异有关的假设。这项研究强调了在微生物群研究和治疗中考虑和潜在考虑种族多样性的必要性。
Composed of hundreds of microbial species, the composition of the human gut microbiota can vary with chronic diseases underlying health disparities that disproportionally affect ethnic minorities. However, the influence of ethnicity on the gut microbiota remains largely unexplored and lacks reproducible generalizations across studies. By distilling associations between ethnicity and differences in two US-based 16S gut microbiota data sets including 1,673 individuals, we report 12 microbial genera and families that reproducibly vary by ethnicity. Interestingly, a majority of these microbial taxa, including the most heritable bacterial family, Christensenellaceae, overlap with genetically associated taxa and form co-occurring clusters linked by similar fermentative and methanogenic metabolic processes. These results demonstrate recurrent associations between specific taxa in the gut microbiota and ethnicity, providing hypotheses for examining specific members of the gut microbiota as mediators of health disparities. Understanding microbiota similarities and differences across ethnicities has the potential to advance approaches aimed at personalized microbial discovery and treatment, particularly those involved in ethnic health disparities. Here, we explore whether or not self-declared ethnicity consistently varies with gut microbiota composition across 1,673 healthy individuals in the United States. We find subtle but significant differences in taxonomic composition between four ethnicities, and we replicate these results across two study populations. Within the gut microbiota of Americans, there are at least 12 microbial taxa, which reproducibly vary in abundance across ethnicities. These taxa tend to correlate in abundance and metabolic functions and overlap with previously identified taxa that are associated with human genetic variation. We discuss the roles these taxa play in digestion and disease and propose hypotheses for how they may relate to ethnic health disparities. This study highlights the need to consider and potentially account for ethnic diversity in microbiota research and therapeutics.
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DOI：
10.1038/ismej.2012.8
发表时间：
2012-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.8
作者：
Fettweis, Jennifer M.;Brooks, J. Paul;Buck, Gregory A.
通讯作者：
Buck, Gregory A.
影响因子：
4.6
作者：
Cao H;Liu X;An Y;Zhou G;Liu Y;Xu M;Dong W;Wang S;Yan F;Jiang K;Wang B
通讯作者：
Wang B
影响因子：
56.9
作者：
Falony, Gwen;Joossens, Marie;Raes, Jeroen
通讯作者：
Raes, Jeroen
影响因子：
3.1
作者：
Castaneda, Garland;Liu, Benny;Wong, Robert J.
通讯作者：
Wong, Robert J.