Structural Characterization of SARS-CoV-2: Where We Are, and Where We Need to Be.

Structural Characterization of SARS-CoV-2: Where We Are, and Where We Need to Be.
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DOI:
10.3389/fmolb.2020.605236
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发表时间:
2020
影响因子:
5
通讯作者:
Bergeron JRC
Bergeron JRC
中科院分区:
生物学3区
文献类型:
--
作者:
Mariano G;Farthing RJ;Lale-Farjat SLM;Bergeron JRC

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严重急性呼吸道综合征冠状病毒2(SARS-CoV-2)在几乎每个国家的人类中迅速传播,导致COVID-19疾病。自COVID-19大流行开始以来,研究工作一直致力于全面了解病毒感染的生物学,以开发疫苗和治疗方法。特别是,结构研究已经允许理解许多SARS-CoV-2蛋白的作用的分子基础,并在治疗和预防治疗方面取得快速进展。尽管这些研究取得了很大进展,但在SARS-CoV-2感染的生物学和分子基础上仍然存在许多知识空白。通过开发有效的治疗方法和具体的疫苗接种战略,填补这些空白将是应对这一流行病的关键。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread in humans in almost every country, causing the disease COVID-19. Since the start of the COVID-19 pandemic, research efforts have been strongly directed towards obtaining a full understanding of the biology of the viral infection, in order to develop a vaccine and therapeutic approaches. In particular, structural studies have allowed to comprehend the molecular basis underlying the role of many of the SARS-CoV-2 proteins, and to make rapid progress towards treatment and preventive therapeutics. Despite the great advances that have been provided by these studies, many knowledge gaps on the biology and molecular basis of SARS-CoV-2 infection still remain. Filling these gaps will be the key to tackle this pandemic, through development of effective treatments and specific vaccination strategies.
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