Structure and Function of Viral Deubiquitinating Enzymes.
Structure and Function of Viral Deubiquitinating Enzymes.
复制标题
病毒去泛素化酶的结构和功能。
DOI：
10.1016/j.jmb.2017.06.010
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发表时间：
2017-11-10
影响因子：
5.6
通讯作者：
Mark BL
中科院分区：
文献类型：
--
作者：
Bailey-Elkin BA;Knaap RCM;Kikkert M;Mark BL
泛素对细胞蛋白的翻译后修饰调节许多细胞过程，包括先天性和适应性免疫应答。泛素介导的对这些过程的控制可以被细胞去泛素化酶（DUB）逆转，所述DUB从细胞靶点去除泛素并使多聚泛素链去磷酸化。蛋白质泛素化对宿主免疫的重要性已经通过编码具有去泛素化活性的蛋白酶的病毒的发现而被强调，其中许多已经被证明积极破坏细胞泛素依赖性过程以抑制先天性抗病毒应答并促进病毒复制。DUB现已在不同的病毒谱系中被鉴定，它们的特征为病毒生物学和泛素系统在宿主抗病毒机制中的作用提供了有价值的见解。在这里，我们提供了这些迷人的病毒酶的结构生物学和它们的作用先天免疫逃避和病毒复制的概述。宿主先天性抗病毒反应的激活在很大程度上依赖于泛素。病毒编码的DUB可以调节先天免疫信号传导。DNA和RNA病毒的结构多样性DUB的分析。病毒DUB对病毒复制和发病至关重要。针对病毒DUB的治疗策略和疫苗接种方法。
Post-translational modification of cellular proteins by ubiquitin regulates numerous cellular processes, including innate and adaptive immune responses. Ubiquitin-mediated control over these processes can be reversed by cellular deubiquitinating enzymes (DUBs), which remove ubiquitin from cellular targets and depolymerize polyubiquitin chains. The importance of protein ubiquitination to host immunity has been underscored by the discovery of viruses that encode proteases with deubiquitinating activity, many of which have been demonstrated to actively corrupt cellular ubiquitin-dependent processes to suppress innate antiviral responses and promote viral replication. DUBs have now been identified in diverse viral lineages, and their characterization is providing valuable insights into virus biology and the role of the ubiquitin system in host antiviral mechanisms. Here, we provide an overview of the structural biology of these fascinating viral enzymes and their role innate immune evasion and viral replication. Activation of host innate antiviral responses is largely ubiquitin-dependent. Virus-encoded DUBs can modulate innate immune signaling. Analysis of structurally diverse DUBs of DNA and RNA viruses. Viral DUBs are critical for virus replication and pathogenesis. Therapeutic strategies and vaccination approaches targeting viral DUBs.
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影响因子：
6.7
作者：
Bailey-Elkin BA;van Kasteren PB;Snijder EJ;Kikkert M;Mark BL
通讯作者：
Mark BL
影响因子：
16
作者：
Békés M;van der Heden van Noort GJ;Ekkebus R;Ovaa H;Huang TT;Lima CD
通讯作者：
Lima CD
影响因子：
3.7
作者：
BRANSOM, KL;WEILAND, JJ;DREHER, TW
通讯作者：
DREHER, TW
影响因子：
5.4
作者：
BURROUGHS, JN;SANGAR, DV;COLLEN, D
通讯作者：
COLLEN, D
DOI：
10.1126/science.1224026
发表时间：
2012-09-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bogunovic D;Byun M;Durfee LA;Abhyankar A;Sanal O;Mansouri D;Salem S;Radovanovic I;Grant AV;Adimi P;Mansouri N;Okada S;Bryant VL;Kong XF;Kreins A;Velez MM;Boisson B;Khalilzadeh S;Ozcelik U;Darazam IA;Schoggins JW;Rice CM;Al-Muhsen S;Behr M;Vogt G;Puel A;Bustamante J;Gros P;Huibregtse JM;Abel L;Boisson-Dupuis S;Casanova JL
通讯作者：
Casanova JL