Using the cavitation collapse time to indicate the extent of histotripsy-induced tissue fractionation.
Using the cavitation collapse time to indicate the extent of histotripsy-induced tissue fractionation.
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DOI：
10.1088/1361-6560/aaae3b
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发表时间：
2018-03-08
影响因子：
3.5
通讯作者：
Xu Z
中科院分区：
文献类型：
--
作者：
Macoskey JJ;Choi SW;Hall TL;Vlaisavljevich E;Lundt JE;Lee FT;Johnsen E;Cain CA;Xu Z
组织切断术是一种基于声空化的超声组织消融方法。研究表明，空化动力学的变化取决于宿主介质的机械特性。在组织解剖治疗过程中，目标组织逐渐分离并最终液化为无细胞匀浆。在这项研究中，研究了组织解剖治疗过程中空化气泡云的塌陷时间（tcol）的变化，作为整个治疗过程中组织分割过程进展的指标。 500kHz 组织解剖传感器用于在不同硬度水平的模拟组织琼脂模型以及离体牛肝脏样本内产生单位置损伤。使用宽带水听器获取空化塌陷信号，并使用高速摄像机在透明的模拟组织模型中对空化进行光学成像。高速相机获得的 tcol 测量结果验证了声学水听器测量结果。随着模型僵硬度的降低以及在整个组织解剖治疗过程中随着施加的脉冲数量的增加，观察到tcol的增加。在整个组织解剖治疗过程中 tcol 的增加趋势与模拟组织模型中产生的病变形成的进展密切相关 (R2 = 0.87)。最后，在离体牛肝中验证了组织解剖治疗中 tcol 的增加趋势。
Histotripsy is an ultrasonic tissue ablation method based on acoustic cavitation. It has been shown that cavitation dynamics change depending on the mechanical properties of the host medium. During histotripsy treatment, the target-tissue is gradually fractionated and eventually liquefied to acellular homogenate. In this study, the change in the collapse time (tcol) of the cavitation bubble cloud over the course of histotripsy treatment is investigated as an indicator for progression of the tissue fractionation process throughout treatment. A 500-kHz histotripsy transducer is used to generate single-location lesions within tissue-mimicking agar phantoms of varying stiffness levels as well as ex vivo bovine liver samples. Cavitation collapse signals are acquired with broadband hydrophones, and cavitation is imaged optically using a high-speed camera in transparent tissue-mimicking phantoms. The high-speed-camera-acquired measurements of tcol validate the acoustic hydrophone measurements. Increases in tcol are observed both with decreasing phantom stiffness and throughout histotripsy treatment with increasing number of pulses applied. The increasing trend of tcol throughout the histotripsy treatment correlates well with the progression of lesion formation generated in tissue-mimicking phantoms (R2 = 0.87). Finally, the increasing trend of tcol over the histotripsy treatment is validated in ex vivo bovine liver.
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DOI：
10.1115/1.3650853
发表时间：
1965-01-01
期刊：
JOURNAL OF BASIC ENGINEERING
影响因子：
--
作者：
IVANY, RD;HAMMITT, FG
通讯作者：
HAMMITT, FG
影响因子：
2.4
作者：
Cleveland, RO;Sapozhnikov, OA;Crum, LA
通讯作者：
Crum, LA
DOI：
10.1109/tuffc.2015.007202
发表时间：
2015-12-01
影响因子：
3.6
作者：
Duryea, Alexander P.;Cain, Charles A.;Hall, Timothy L.
通讯作者：
Hall, Timothy L.
影响因子：
2.4
作者：
OHL, CD;PHILIPP, A;LAUTERBORN, W
通讯作者：
LAUTERBORN, W
影响因子：
2.9
作者：
Macoskey, Jonathan J.;Zhang, Xi;Xu, Zhen
通讯作者：
Xu, Zhen