Evaluation of Regional Differences of Tracer Appearance Time in Cerebral Tissues Using [15O]Water and Dynamic Positron Emission Tomography
Evaluation of Regional Differences of Tracer Appearance Time in Cerebral Tissues Using [15O]Water and Dynamic Positron Emission Tomography
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使用[15O]水和动态正电子发射断层扫描评估脑组织中示踪剂出现时间的区域差异
DOI：
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发表时间：
1988
影响因子：
6.3
通讯作者：
K. Uemura
中科院分区：
文献类型：
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作者：
H. Iida;S. Higano;N. Tomura;F. Shishido;I. Kanno;S. Miura;M. Murakami;K Takahashi;H. Sasaki;K. Uemura
示踪剂的出现时间相对于桡动脉采样网站已在六个大脑位置在五个人类受试者使用动态正电子发射断层扫描（PET）团注H215O进行了评价。每个位置的平均值最大差异为± 2 s。为了全局调整测量的动脉曲线和PET扫描之间的时间差，开发了基于非线性最小二乘拟合过程的校正方法。这种新技术确定了全局时间延迟，精度为± 0.5 s。另一方面，线性后向外推法导致4s的系统误差。
The tracer appearance time relative to the radial artery–sampling site has been evaluated in six brain locations in five human subjects using dynamic positron emission tomography (PET) following the bolus injection of H215O. There was a maximum difference of ± 2 s from the average in each location. T o globally adjust the timing difference between the measured arterial curve and the PET scan, a correction method was developed based on a nonlinear least-squares fitting procedure. This new technique determined the global time delay with an accuracy of ± 0.5 s. On the other hand, the linear backward extrapolation method resulted in a systematic error of 4 s.
DOI：
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发表时间：
1983-09
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
M. Raichle;W. Martin;P. Herscovitch;M. Mintun;J. Markham
通讯作者：
M. Raichle;W. Martin;P. Herscovitch;M. Mintun;J. Markham