The Role of Ras-Associated Protein 1 (Rap1) in Cancer: Bad Actor or Good Player?
The Role of Ras-Associated Protein 1 (Rap1) in Cancer: Bad Actor or Good Player?
复制标题
DOI：
10.3390/biomedicines8090334
复制
发表时间：
2020-09-07
期刊：
影响因子：
4.7
通讯作者：
Mai CW
中科院分区：
文献类型：
--
作者：
Looi CK;Hii LW;Ngai SC;Leong CO;Mai CW
转移被认为是癌症患者中最危及生命的事件。原则上，免疫系统可以防止肿瘤的发展。然而，功能失调的T细胞可能无法有效地消除肿瘤细胞，并为肿瘤增殖和转移提供额外的生存优势。Ras相关蛋白1（Rap1）的组成性激活不仅导致T细胞无反应性，而且还抑制自噬并通过各种致癌事件支持癌症进展。抑制Rap1活性及其负调节因子Rap1GAP会损害肿瘤进展。然而，活性Rap1减少了某些癌症的肿瘤侵袭，表明Rap1信号在癌症中的多效性效应可能是癌症特异性的。总而言之，靶向Rap1信号及其调节因子可能潜在地控制癌的发生、转移、化疗耐药性和免疫逃避。Rap1GAP可能是一个很有前途的抗癌治疗靶点。
Metastasis is known as the most life-threatening event in cancer patients. In principle, the immune system can prevent tumor development. However, dysfunctional T cells may fail to eliminate the tumor cells effectively and provide additional survival advantages for tumor proliferation and metastasis. Constitutive activation of Ras-associated protein1 (Rap1) has not only led to T cell anergy, but also inhibited autophagy and supported cancer progression through various oncogenic events. Inhibition of Rap1 activity with its negative regulator, Rap1GAP, impairs tumor progression. However, active Rap1 reduces tumor invasion in some cancers, indicating that the pleiotropic effects of Rap1 signaling in cancers could be cancer-specific. All in all, targeting Rap1 signaling and its regulators could potentially control carcinogenesis, metastasis, chemoresistance and immune evasion. Rap1GAP could be a promising therapeutic target in combating cancer.
登录
查看更多内容
Rap1 可稳定 β-连环蛋白并增强头颈部鳞状细胞癌中 β-连环蛋白依赖性转录和侵袭。
DOI：
10.1158/1078-0432.ccr-09-1122
发表时间：
2010-01-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Goto M;Mitra RS;Liu M;Lee J;Henson BS;Carey T;Bradford C;Prince M;Wang CY;Fearon ER;D'Silva NJ
通讯作者：
D'Silva NJ
影响因子：
20.3
作者：
Carmona, Guillaume;Goettig, Stephan;Chavakis, Emmanouil
通讯作者：
Chavakis, Emmanouil
影响因子：
3.8
作者：
Hii, Ling-Wei;Chung, Felicia Fei-Lei;Leong, Chee-Onn
通讯作者：
Leong, Chee-Onn
影响因子：
7.5
作者：
Efeyan A;Sabatini DM
通讯作者：
Sabatini DM
影响因子：
--
作者：
Goldsmith J;Levine B;Debnath J
通讯作者：
Debnath J