Rhythmicity of intestinal IgA responses confers oscillatory commensal microbiota mutualism.
Rhythmicity of intestinal IgA responses confers oscillatory commensal microbiota mutualism.
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DOI：
10.1126/sciimmunol.abk2541
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发表时间：
2022-09-02
影响因子：
24.8
通讯作者：
Hepworth MR
中科院分区：
文献类型：
--
作者：
Penny HA;Domingues RG;Krauss MZ;Melo-Gonzalez F;Lawson MAE;Dickson S;Parkinson J;Hurry M;Purse C;Jegham E;Godinho-Silva C;Rendas M;Veiga-Fernandes H;Bechtold DA;Grencis RK;Toellner KM;Waisman A;Swann JR;Gibbs JE;Hepworth MR
哺乳动物宿主和共生微生物区系之间的相互作用是通过一系列免疫反应来加强的，这些免疫反应赋予新陈代谢益处，并促进组织健康和动态平衡。免疫球蛋白A(IgA)的反应直接决定了寄生在肠道的共生物种的组成，但需要大量的代谢资源来推动组织内浆细胞产生抗体。在这里，我们证明了免疫球蛋白A的反应在一天的昼夜节律过程中受到昼夜调节。具体地说，发现IgA分泌的大小以及组织驻留的IgA+浆细胞的转录组表现出节律性。振荡的IgA反应被发现被喂食的时间所携带，并且部分地被浆细胞固有的生物钟协调。此外，宿主和微生物区系之间的相互作用以依赖于IgA的方式决定了共生微生物群落之间的振荡动力学及其相关的转录和代谢活动。综上所述，我们的发现表明，由肠道IgA、饮食和微生物区系组成的昼夜网络融合在一起，以对齐肠道中的昼夜生物学，并确保宿主-微生物互惠共生。
Interactions between the mammalian host and commensal microbiota are enforced through a range of immune responses that confer metabolic benefits and promote tissue health and homeostasis. Immunoglobulin A (IgA) responses directly determine the composition of commensal species that colonize the intestinal tract but require significant metabolic resources to fuel antibody production by tissue-resident plasma cells. Here we demonstrate IgA responses are subject to diurnal regulation over the course of a circadian day. Specifically, the magnitude of IgA secretion, as well as the transcriptome of tissue-resident IgA+ plasma cells, were found to exhibit rhythmicity. Oscillatory IgA responses were found to be entrained by time of feeding, and in-part coordinated by the plasma cell-intrinsic circadian clock. Moreover, reciprocal interactions between the host and microbiota dictated oscillatory dynamics amongst the commensal microbial community and its associated transcriptional and metabolic activity, in an IgA-dependent manner. Together our findings suggest circadian networks comprising intestinal IgA, the diet and the microbiota converge to align circadian biology in the intestinal tract and to ensure host-microbial mutualism.
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影响因子：
5.8
作者：
Gu, Zuguang;Eils, Roland;Schlesner, Matthias
通讯作者：
Schlesner, Matthias
影响因子：
32.4
作者：
Bunker JJ;Flynn TM;Koval JC;Shaw DG;Meisel M;McDonald BD;Ishizuka IE;Dent AL;Wilson PC;Jabri B;Antonopoulos DA;Bendelac A
通讯作者：
Bendelac A
DOI：
10.1038/nrmicro.2016.196
发表时间：
2017-04
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
Johnson CH;Zhao C;Xu Y;Mori T
通讯作者：
Mori T
影响因子：
17.1
作者：
Fadlallah, Jehane;El Kafsi, Hela;Gorochov, Guy
通讯作者：
Gorochov, Guy
DOI：
10.1056/nejmra1802337
发表时间：
2021-02-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
Allada R;Bass J
通讯作者：
Bass J