Pneumococcal infections in children with sickle cell disease before and after pneumococcal conjugate vaccines.
Pneumococcal infections in children with sickle cell disease before and after pneumococcal conjugate vaccines.
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DOI：
10.1182/bloodadvances.2022009643
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发表时间：
2023-11-14
期刊：
影响因子：
7.5
通讯作者：
Yildirim, Inci
中科院分区：
文献类型：
--
作者：
Adamkiewicz, Thomas, V;Yee, Marianne E. M.;Thomas, Stepy;Tunali, Amy;Lai, Kristina W.;Omole, Folashade S.;Lane, Peter A.;Yildirim, Inci
感染PCV7/PCV13后，SCD患儿的侵袭性肺炎球菌感染已显著下降，但仍有危及生命的危险。PPSV23和新疫苗PCV15、PCV20和PCV21分别包括62%、16%、51%和92%未包括在PCV13中的IPD血清型。患有镰状细胞病（SCD）的儿童患侵袭性肺炎球菌病（IPD）的风险增加。25年来，乔治亚州新发感染项目/疾病控制和预防中心活性细菌核心监测网络在3707名血红蛋白SS （HbSS）或年龄<10岁的HbSC儿童中发现104例IPD发作，占居住在亚特兰大大都会（参考人群）的黑人或非裔美国儿童IPD的6%。在参考人群中，患有IPD和HbSS/SC的儿童比患有IPD的儿童年龄大（P < 0.001）。从1994-1999年到2010-2018年，0- 4岁HbSS儿童的IPD下降了87%，5 - 9岁儿童的IPD下降了80%。然而，在此期间，当将SCD儿童与参考人群进行比较时，IPD发病率比从20.2增加到29.2。2002年后，患有乙型肝炎链球菌感染和IPD的儿童死亡率从14%下降到3%，脑膜炎从16%下降到8%。在7价肺炎球菌结合疫苗（PCV7）获得许可之前，青霉素耐药性在SCD儿童中更为普遍。2010年以后，13价PCV （PCV13）不再包括所有IPD血清型。接种3年内，23价肺炎球菌多糖疫苗（PPSV23）对PPSV23 + 15A/15C中包括的非pcv13血清型的有效性为92%（95%置信区间为40.8- 99.0,P = 0.014；根据年龄和羟基脲调整了间接队列效应）。PPSV23将覆盖62%的SCD儿童非pcv13血清型IPD，而PCV15、PCV20和PCV21/V116（正在开发）分别可以覆盖16%、51%和92%。虽然发生的频率较低，但IPD仍然是SCD患儿危及生命的危险。覆盖面更广的有效疫苗可使这些儿童受益。
Invasive pneumococcal infection in children with SCD has declined significantly with PCV7/PCV13 but remains a life-threatening risk. PPSV23 and new vaccines PCV15, PCV20, and PCV21 include 62%, 16%, 51%, and 92% of IPD serotypes not included in PCV13, respectively. Children with sickle cell disease (SCD) are at increased risk of invasive pneumococcal disease (IPD). Over 25 years, the Georgia Emerging Infections Program/Centers for Disease Control and Prevention Active Bacterial Core Surveillance network identified 104 IPD episodes among 3707 children with hemoglobin SS (HbSS) or HbSC aged <10 years, representing 6% of IPD in Black or African American children residing in Metropolitan Atlanta (reference population). Children with IPD and HbSS/SC were older than those with IPD in the reference population (P < .001). From 1994-1999 to 2010-2018, IPD declined by 87% in children with HbSS aged 0 to 4 years, and by 80% in those aged 5 to 9 years. However, IPD incidence rate ratios when comparing children with SCD with the reference population increased from 20.2 to 29.2 over these periods. Among children with HbSS and IPD, death declined from 14% to 3% after 2002, and meningitis declined from 16% to 8%. Penicillin resistance was more prevalent in children with SCD before 7-valent pneumococcal conjugate vaccine (PCV7) licensure. After 2010, all IPD serotypes were not included in the 13-valent PCV (PCV13). Within 3 years of vaccination, the effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPSV23) against non-PCV13 serotypes included in PPSV23 plus 15A/15C was 92% (95% confidence interval, 40.8- 99.0, P = .014; indirect-cohort effect adjusted for age and hydroxyurea). PPSV23 would cover 62% of non-PCV13 serotype IPD in children with SCD, whereas PCV15, PCV20, and PCV21/V116 (in development) could cover 16%, 51%, and 92%, respectively. Although less frequent, IPD remains a life-threatening risk in children with SCD. Effective vaccines with broader coverage could benefit these children.
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DOI：
10.1016/s2214-109x(21)00165-0
发表时间：
2021-07
期刊：
The Lancet. Global health
影响因子：
--
作者：
Bar-Zeev N;Swarthout TD;Everett DB;Alaerts M;Msefula J;Brown C;Bilima S;Mallewa J;King C;von Gottberg A;Verani JR;Whitney CG;Mwansambo C;Gordon SB;Cunliffe NA;French N;Heyderman RS;VacSurv Consortium
通讯作者：
VacSurv Consortium
影响因子：
3.7
作者：
Dayie NTKD;Tetteh-Ocloo G;Labi AK;Olayemi E;Slotved HC;Lartey M;Donkor ES
通讯作者：
Donkor ES
影响因子：
5.5
作者：
Blum, MD;Dagan, R;McNeely, TB
通讯作者：
McNeely, TB
影响因子：
5.1
作者：
FALLETTA, JM;WOODS, GM;REID, C
通讯作者：
REID, C
影响因子：
2.9
作者：
Archer NM;Inusa B;Makani J;Nkya S;Tshilolo L;Tubman VN;McGann PT;Ambrose EE;Henrich N;Spector J;Ohene-Frempong K
通讯作者：
Ohene-Frempong K