In Vitro Cellular Strain Models of Tendon Biology and Tenogenic Differentiation.
In Vitro Cellular Strain Models of Tendon Biology and Tenogenic Differentiation.
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DOI：
10.3389/fbioe.2022.826748
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发表时间：
2022
影响因子：
5.7
通讯作者：
Kremen TJ Jr
中科院分区：
文献类型：
--
作者：
Wu SY;Kim W;Kremen TJ Jr
研究表明，周围的生物力学环境在肌腱的发育、分化、修复和降解中起着重要作用，但肌腱细胞与它们所经历的力之间的相互作用是复杂的。体外机械刺激模型试图了解机械负荷对肌腱和结缔组织祖细胞的影响。本文综述了用于研究肌腱力学生物学的多种机械刺激模型，并概述了目前在模拟肌腱复杂的天然生物力学环境方面的进展。虽然在推进对机械刺激在肌腱发育、损伤和修复中的作用的理解方面取得了很大进展，但还没有理想的体外模型。进一步的比较研究和仔细考虑的负载参数，细胞群，和生化添加剂可能会进一步提供新的见解，一个理想的模型，支持肌腱再生研究。
Research has shown that the surrounding biomechanical environment plays a significant role in the development, differentiation, repair, and degradation of tendon, but the interactions between tendon cells and the forces they experience are complex. In vitro mechanical stimulation models attempt to understand the effects of mechanical load on tendon and connective tissue progenitor cells. This article reviews multiple mechanical stimulation models used to study tendon mechanobiology and provides an overview of the current progress in modelling the complex native biomechanical environment of tendon. Though great strides have been made in advancing the understanding of the role of mechanical stimulation in tendon development, damage, and repair, there exists no ideal in vitro model. Further comparative studies and careful consideration of loading parameters, cell populations, and biochemical additives may further offer new insight into an ideal model for the support of tendon regeneration studies.
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DOI：
10.1115/1.1318906
发表时间：
2000-12-01
影响因子：
1.7
作者：
Butler, DL;Goldstein, SA;Guilak, F
通讯作者：
Guilak, F
影响因子：
16.1
作者：
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影响因子：
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作者：
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影响因子：
2.9
作者：
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通讯作者：
Young, Tai-Horng
影响因子：
4.5
作者：
Cheng, Vinton W. T.;Screen, Hazel R. C.
通讯作者：
Screen, Hazel R. C.