Expression profiling reveals differential gene induction underlying specific and non-specific memory for pheromones in mice.
Expression profiling reveals differential gene induction underlying specific and non-specific memory for pheromones in mice.
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DOI：
10.1016/j.neuint.2011.08.009
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发表时间：
2011-11
影响因子：
4.2
通讯作者：
Hegde AN
中科院分区：
文献类型：
--
作者：
Upadhya SC;Smith TK;Brennan PA;Mychaleckyj JC;Hegde AN
雌性小鼠对交配雄性信息素的记忆被认为需要副嗅球（AOB）的突触变化。这种记忆的诱导依赖于谷氨酸的释放，以响应信息素暴露与交配后AOB中去甲肾上腺素（NE）的释放一致。对信息素的类似记忆也可以通过将GABAA受体拮抗剂荷包牡丹碱局部输注到AOB中来人工诱导。在交配过程中暴露于信息素而形成的自然记忆是特定于雌性在交配过程中感受到的信息素的。相比之下，荷包牡丹碱诱导的人工记忆是非特异性的，导致雌性小鼠识别所有信息素，就好像它们来自交配的雄性一样。虽然蛋白质合成已被证明是必不可少的信息素记忆的发展，基因表达级联记忆形成的关键是不知道的。我们研究了在交配诱导的信息素记忆（MIPM）以及荷包牡丹碱诱导的信息素记忆（BIPM）过程中，使用寡核苷酸微阵列在AOB基因表达的变化。我们发现在MIPM和BIPM期间诱导的基因组在很大程度上是不重叠的，并且不相容性通路分析揭示了MIPM和BIPM中的信号通路也不同。MIPM过程中诱导的基因产物与突触功能相关，表明特定突触修饰的可能性，而BIPM过程中诱导的基因产物似乎具有神经元范围的功能，这与整体细胞变化一致。因此，这些结果开始提供一个机制解释的信息素和荷包牡丹碱输液分别诱导的特异性和非特异性记忆。
Memory for the mating male’s pheromones in female mice is thought to require synaptic changes in the accessory olfactory bulb (AOB). Induction of this memory depends on release of glutamate in response to pheromonal exposure coincident with release of norepinephrine (NE) in the AOB following mating. A similar memory for pheromones can also be induced artificially by local infusion of the GABAA receptor antagonist bicuculline into the AOB. The natural memory formed by exposure to pheromones during mating is specific to the pheromones sensed by the female during mating. In contrast, the artificial memory induced by bicuculline is non-specific and results in the female mice recognizing all pheromones as if they were from the mating male. Although protein synthesis has been shown to be essential for development of pheromone memory, the gene expression cascades critical for memory formation are not known. We investigated changes in gene expression in the AOB using oligonucleotide microarrays during mating-induced pheromone memory (MIPM) as well as bicuculline-induced pheromone memory (BIPM). We found the set of genes induced during MIPM and BIPM are largely non-overlapping and Ingenuity Pathway Analysis revealed that the signaling pathways in MIPM and BIPM also differ. The products of genes induced during MIPM are associated with synaptic function, indicating the possibility of modification at specific synapses, while those induced during BIPM appear to possess neuron-wide functions, which would be consistent with global cellular changes. Thus, these results begin to provide a mechanistic explanation for specific and non-specific memories induced by pheromones and bicuculline infusion respectively.
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影响因子：
7.8
作者：
Bao, JX;Wolpowitz, D;Role, LW;Talmage, DA
通讯作者：
Talmage, DA
影响因子：
2.7
作者：
Etienne, W;Meyer, MH;Meyer, RA
通讯作者：
Meyer, RA
影响因子：
25
作者：
Fischer, M;Kaech, S;Matus, A
通讯作者：
Matus, A
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
2.9
作者：
Cheetham, Sarah A.;Smith, Abigail L.;Hurst, Jane L.
通讯作者：
Hurst, Jane L.