Distribution of ingenol derivatives in Euphorbia plants and UV-dependent promotion of ingenol production in greenhouse-grown Euphorbia plants
Distribution of ingenol derivatives in Euphorbia plants and UV-dependent promotion of ingenol production in greenhouse-grown Euphorbia plants
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大戟属植物中巨大戟二萜醇衍生物的分布以及温室大戟属植物中巨大戟二萜醇产生的紫外线依赖性促进
DOI：
10.1016/j.indcrop.2021.114111
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发表时间：
2021-12
影响因子：
5.9
通讯作者：
Chen Yu
中科院分区：
文献类型：
--
作者：
Chen Meixiang;Tian Mei;Liu Fei;Zhao Wanli;Peng Jian;Li Linwei;Yin Min;Gu Yonghua;Feng Xu;Chen Yu
Resource discovery for producing biologically active phytochemicals plays an important role in industrial crops area. Ingenol-3-angelate, one of the most concerned macrocyclic diterpenoids, has been approved for clinical treatment of actinic keratosis and industrially produced by a semi-synthesis approach using hydrolysis products of ingenol derivatives. Ingenol derivatives are considered exclusive amongEuphorbiagenus at a quite low level. In search for high-ingenol plant species from the Euphorbiaceae family, ultra-high performance liquid chromatography coupled with mass spectrometry (UHPLC-MS) was performed for the quantitative analysis of the free ingenol content in the hydrolyzed methanol extract of 61 selected plant species, including 50Euphorbiaplants, 9 plants from other Euphorbiaceae genera, and 2 Phyllanthaceae plants. The ingenol derivatives inE. miliiandE. cotinifoliawhich contained high level of ingenol esters were further identified by UHPLC-MS. Amounts of ingenol diterpenes varied among the samples. The highest free ingenol content (527.82 ± 38.19 μmol/kg of dry herb weight) was found in a variation,E. tithymaloides'Nanus', followed byE. tithymaloides(402.81 ± 28.89 μmol/kg),E. milii(391.30 ± 43.51 μmol/kg),E. ammak(379.75 ± 34.68 μmol/kg), andE. trigona(357.07 ± 34.29 μmol/kg). The results revealed the trace amount of ingenol derivatives in someJatropha, Acalypha, Codiaeum, andExcoecariaplants for the first time and confirmed the higher level of ingenol esters in someEuphorbiaplants cultivated under polycarbonate panel with higher UV transmission than those grown under double layer glass. The secondary metabolites varied distinctively among differentEuphorbiasections. This work suggested more applicable sources for ingenol production and better greenhouse covering material forEuphorbiaplants cultivation in consideration of ingenol derivatives.
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影响因子：
3.4
作者：
Dorsey, Brian L.;Haevermans, Thomas;Berry, Paul E.
通讯作者：
Berry, Paul E.
影响因子：
6.7
作者：
Liu Q;Li W;Huang L;Asada Y;Morris-Natschke SL;Chen CH;Lee KH;Koike K
通讯作者：
Koike K
影响因子：
3.8
作者：
C. Zani;A. Marston;M. Hamburger;K. Hostettmann
通讯作者：
C. Zani;A. Marston;M. Hamburger;K. Hostettmann
影响因子：
4.1
作者：
M. Girin;S. Paphassarang;C. David-Eteve;A. Chaboud;J. Raynaud
通讯作者：
M. Girin;S. Paphassarang;C. David-Eteve;A. Chaboud;J. Raynaud
影响因子：
2.2
作者：
A. M. Sobottka;C. Görick;Matthias F. Melzig
通讯作者：
A. M. Sobottka;C. Görick;Matthias F. Melzig