Extracting Latent Subdimensions of Social Communication: A Cross-Measure Factor Analysis.
Extracting Latent Subdimensions of Social Communication: A Cross-Measure Factor Analysis.
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DOI：
10.1016/j.jaac.2020.08.444
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发表时间：
2021-06
影响因子：
13.3
通讯作者：
Bishop SL
中科院分区：
文献类型：
--
作者：
Zheng S;Kaat A;Farmer C;Kanne S;Georgiades S;Lord C;Esler A;Bishop SL
与自闭症谱系障碍（ASD）相关的社会沟通缺陷通常表示为一个行为领域。然而，需要提高社会沟通测量的精度，以促进自闭症谱系内和诊断界限之间更细微的表型分析。从四个数据源中汇总了一个4至10岁儿童的大样本（N=1470），然后随机分为测试和验证样本。在多特质/多方法因素分析框架下，对三种广泛使用的孤独症症状量表（ADOS、ADI-R、SRS）中的57个社交项目进行了分析。然后使用验证样品确认所选模型。根据拟合指数，使用测试样品选择具有三个正交方法因素的四个物质因素模型，然后使用验证样品进行确认。其中两个因素，“基本社会沟通技能”和“互动质量”，与先前对ADOS模块3的分析中确定的因素相似（Bishop等人，2016年）。另外两个因素，“同伴互动和行为的改变”和“社会启蒙和归属”也出现了。因子得分与年龄和语言智商呈名义相关。子维度的识别可以为创建更好的社交沟通障碍概念模型提供信息，包括绘制社交沟通缺陷的级联效应如何在ASD与其他疾病中展开。特别是如果扩展到包括年龄较大和较年轻的群体以及具有更不同发育水平的个体，这些努力可以通过精确定位导致各种类型的社会沟通缺陷的特定机制，为基于表型的生物和遗传机制探索提供信息。
Social communication deficits associated with autism spectrum disorder (ASD) are commonly represented as one behavioral domain. However, increased precision of measurement of social communication is needed to promote more nuanced phenotyping both within the autism spectrum and across diagnostic boundaries. A large sample (N=1470) of 4-to-10-year-old children was aggregated from across four data sources, and then randomly split into testing and validation samples. Fifty-seven selected social communication items from three widely used autism symptom measures (ADOS, ADI-R, SRS) were analyzed in the multi-trait/multi-method factor analysis framework. The selected model was then confirmed with the validation sample. The four substantive-factor model, with three orthogonal method factors, was selected using the testing sample based on fit indices and then confirmed with the validation sample. Two of the factors, “Basic Social Communication Skills” and “Interaction Quality,” were similar to those identified in a previous analysis of the ADOS, Module 3 (Bishop et al., 2016). Two additional factors, “Peer Interaction and Modification of Behavior” and “Social Initiation and Affiliation,” also emerged. Factor scores showed nominal correlations with age and verbal IQ. Identification of subdimensions could inform the creation of better conceptual models of social communication impairments, including mapping of how the cascading effects of social communication deficits unfold in ASD vs. other disorders. Especially if extended to include both older and younger age cohorts and individuals with more varying developmental levels, these efforts could inform phenotype-based exploration for biological and genetic mechanisms by pinpointing specific mechanisms that contribute to various types of social communication deficits.
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DOI：
10.1016/j.jaac.2018.09.431
发表时间：
2019-09-01
影响因子：
13.3
作者：
Kim, Hyunsik;Keifer, Cara;Gadow, Kenneth
通讯作者：
Gadow, Kenneth
自闭症诊断观察表： 提高诊断有效性的修订算法
影响因子：
3.9
作者：
Gotham, Katherine;Risi, Susan;Lord, Catherine
通讯作者：
Lord, Catherine
DOI：
10.1016/j.jaac.2016.09.490
发表时间：
2016-12-01
影响因子：
13.3
作者：
Havdahl, Karoline Alexandra;Bal, Vanessa Hus;Bishop, Somer L.
通讯作者：
Bishop, Somer L.
DOI：
10.1111/jcpp.12510
发表时间：
2016-08
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
Bishop SL;Havdahl KA;Huerta M;Lord C
通讯作者：
Lord C
影响因子：
3.9
作者：
Grzadzinski, Rebecca;Di Martino, Adriana;Brady, Emily;Angeles Mairena, Maria;O'Neale, Matthew;Petkova, Eva;Lord, Catherine;Castellanos, F. Xavier
通讯作者：
Castellanos, F. Xavier