Assessment of pain-related behaviors in HIV-1 transgenic rats as a model of HIV-associated chronic pain.
Assessment of pain-related behaviors in HIV-1 transgenic rats as a model of HIV-associated chronic pain.
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DOI：
10.1177/17448069231213554
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发表时间：
2023-01
期刊：
影响因子：
3.3
通讯作者：
中科院分区：
文献类型：
--
作者：
人类免疫缺陷病毒-1（HIV）相关慢性疼痛是一种使人衰弱的共病，影响25-85%的HIV感染者。使用阿片类药物缓解疼痛导致该队列中出现阿片类药物依赖。因此，迫切需要了解HIV相关慢性疼痛的机制并确定新的治疗方法。已经开发了几种动物模型来研究HIV相关的合并症。HIV-1转基因（Tg）大鼠已被证明是一种可靠的模型，可以模拟在HIV感染者中观察到的缺陷，如神经系统和免疫系统的改变。然而，这些动物的疼痛相关行为尚未得到广泛评价。在这项研究中，我们测量了诱发和自发行为的HIV-1 Tg雄性和雌性大鼠。结果表明，HIV-1 Tg大鼠表现出与HIV-1相关神经病变大鼠相似的行为，特别是冷敏感性。因此，HIV-1 Tg大鼠可以作为神经病变模型，以研究针对HIV-1感染者的疼痛相关机制和治疗方法。
Human immunodeficiency virus-1 (HIV)-associated chronic pain is a debilitating comorbid condition that affects 25–85% of people with HIV. The use of opioids to alleviate pain has given rise to opioid dependency in this cohort. Therefore, there is an urgent need to understand mechanisms and identify novel therapeutics for HIV-associated chronic pain. Several animal models have been developed to study HIV-related comorbidities. HIV-1 transgenic (Tg) rats have been shown to serve as a reliable model that mimic the deficits observed in people with HIV, such as neurological and immune system alterations. However, pain-related behavior in these animals has not been extensively evaluated. In this study, we measured evoked and spontaneous behavior in HIV-1Tg male and female rats. The results indicated that HIV-1Tg rats exhibit similar behavior to those with HIV-1-related neuropathy, specifically, cold sensitivity. Consequently, HIV-1Tg rats can serve as a model of neuropathy to study pain-related mechanisms and therapeutics targeted toward individuals living with HIV-1.
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影响因子：
7
作者：
Chatterjee, Tanima;Arora, Itika;Underwood, Lilly;Gryshyna, Anastasiia;Lewis, Terry L.;Masjoan Juncos, Juan Xavier;Goodin, Burel R.;Heath, Sonya;Aggarwal, Saurabh
通讯作者：
Aggarwal, Saurabh
DOI：
10.1073/pnas.1609057113
发表时间：
2016-08-02
影响因子：
11.1
作者：
Imamichi, Hiromi;Dewar, Robin L.;Lane, H. Clifford
通讯作者：
Lane, H. Clifford
影响因子：
11.4
作者：
Aggarwal, Saurabh;DeBerry, Jennifer J.;Matalon, Sadis
通讯作者：
Matalon, Sadis
影响因子：
7.4
作者：
Bouhassira, D;Attal, N;Brasseur, L
通讯作者：
Brasseur, L
影响因子：
3.1
作者：
Goodin, Burel R.;Owens, Michael A.;Merlin, Jessica S.
通讯作者：
Merlin, Jessica S.