On the nature and function of organizers.
On the nature and function of organizers.
复制标题
论组织者的性质和功能。
DOI：
10.1242/dev.159525
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发表时间：
2018-03-09
期刊：
影响因子：
--
通讯作者：
Steventon B
中科院分区：
文献类型：
--
作者：
Martinez Arias A;Steventon B
组织者，由具有指示相邻细胞进入特定状态的能力的细胞群组成，代表了发育生物学中的一个关键原则。这个概念最早是由Spemann和Mangold提出的，他们指出蝾螈胚胎中存在一个细胞群体，促使相邻细胞发育出次级轴。随后在鸡和兔胚胎中进行的类似实验揭示了具有类似指导潜力的细胞群。在鸟类和哺乳动物中，组织者活动通常与一种被称为节点的结构有关，因此被认为是Spemann组织者的功能同源物。在这里，我们深入研究了跨物种的组织者的结构和功能，并注意到，两栖动物的组织者是一个偶然的元素集合，每个元素执行一个特定的功能，而其他物种的组织者元素在时间和空间上是分散的。这一观察促使我们重新思考组织者概念的普遍性和意义。摘要：本综述重新评估了Spemann’s组织者的概念，并在两栖动物中发现，强调了等效元素在小鼠中的时空分散以及对组织者信号的响应性的关键影响。
Organizers, which comprise groups of cells with the ability to instruct adjacent cells into specific states, represent a key principle in developmental biology. The concept was first introduced by Spemann and Mangold, who showed that there is a cellular population in the newt embryo that elicits the development of a secondary axis from adjacent cells. Similar experiments in chicken and rabbit embryos subsequently revealed groups of cells with similar instructive potential. In birds and mammals, organizer activity is often associated with a structure known as the node, which has thus been considered a functional homologue of Spemann's organizer. Here, we take an in-depth look at the structure and function of organizers across species and note that, whereas the amphibian organizer is a contingent collection of elements, each performing a specific function, the elements of organizers in other species are dispersed in time and space. This observation urges us to reconsider the universality and meaning of the organizer concept. Summary: This Review re-evaluates the notion of Spemann's organizer as identified in amphibians, highlighting the spatiotemporal dispersion of equivalent elements in mouse and the key influence of responsiveness to organizer signals.
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影响因子：
16.6
作者：
Anderson, Claire;Khan, Mohsin A. F.;Wong, Frances;Solovieva, Tatiana;Oliveira, Nidia M. M.;Baldock, Richard A.;Tickle, Cheryll;Burt, Dave W.;Stern, Claudio D.
通讯作者：
Stern, Claudio D.
影响因子：
64.8
作者：
Essner, JJ;Vogan, KJ;Brueckner, M
通讯作者：
Brueckner, M
影响因子：
2.9
作者：
Blum, Martin;Andre, Philipp;Viebahn, Christoph
通讯作者：
Viebahn, Christoph
影响因子：
2.7
作者：
Davidson, BP;Kinder, SJ;Tam, PPL
通讯作者：
Tam, PPL
DOI：
10.1002/jez.b.21325
发表时间：
2010-05-15
影响因子：
2.2
作者：
Finch, Emma;Cruz, Carlos;Kudoh, Tetsuhiro
通讯作者：
Kudoh, Tetsuhiro