RNA around the clock - regulation at the RNA level in biological timing.

RNA around the clock - regulation at the RNA level in biological timing.
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DOI:
10.3389/fpls.2015.00311
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发表时间:
2015
影响因子:
5.6
通讯作者:
Staiger D
Staiger D
中科院分区:
生物学2区
文献类型:
--
作者:
Nolte C;Staiger D

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植物的昼夜节律系统使植物的生理功能与外界环境相协调。这是通过对基因表达程序的全局控制来实现的,其中相当一部分转录组在稳态丰度下经历24小时振荡。这些昼夜节律振荡是由一组核心时钟蛋白驱动的,这些蛋白通过对自身转录的周期性反馈产生自己的24小时节律。此外,转录后事件有助于核心时钟基因和时钟输出基因的振荡。在这里,我们提供了在RNA水平上的分子事件,有助于核心时钟蛋白的24小时节律和形状的昼夜节律转录组的更新。我们专注于模式植物拟南芥的昼夜节律系统,但也讨论了在其他生物体中选择的监管原则。
The circadian timing system in plants synchronizes their physiological functions with the environment. This is achieved by a global control of gene expression programs with a considerable part of the transcriptome undergoing 24-h oscillations in steady-state abundance. These circadian oscillations are driven by a set of core clock proteins that generate their own 24-h rhythm through periodic feedback on their own transcription. Additionally, post-transcriptional events are instrumental for oscillations of core clock genes and genes in clock output. Here we provide an update on molecular events at the RNA level that contribute to the 24-h rhythm of the core clock proteins and shape the circadian transcriptome. We focus on the circadian system of the model plant Arabidopsis thaliana but also discuss selected regulatory principles in other organisms.
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