[Specificity of plasma peroxidized low density lipoprotein in lung cancer].
[Specificity of plasma peroxidized low density lipoprotein in lung cancer].
复制标题
血浆过氧化低密度脂蛋白在肺癌中的特异性
DOI：
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
H. Takase
中科院分区：
文献类型：
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作者：
H. Takase
肺癌患者38例，动脉粥样硬化性疾病患者20例，健康人32例。连续超速离心后测定低密度脂蛋白(LDL)的过氧化脂质和脂质成分。低密度脂蛋白中的脂质过氧化水平依次为：LC>；AS>；H-胆固醇酯、甘油三酯、游离脂肪酸、游离胆固醇和磷脂。而动脉粥样硬化性疾病患者甘油三酯与游离脂肪酸之间的X1斑点，游离脂肪酸与游离胆固醇之间的X2斑点清晰可见，肺癌患者的X1斑点除上述脂质成分外，均有少量着色。不同组织学类型肺癌患者的脂类成分无明显差异。肺癌和动脉粥样硬化性疾病患者的脂质过氧化水平明显高于正常人，但肺癌患者和动脉粥样硬化性疾病患者的低密度脂蛋白过氧化成分有显著差异。
Plasma was sampled from patients with lung cancer (LC: n = 38), patients with atherosclerotic disease (AS: n = 20), and healthy persons (H: n = 32). Lipid peroxide and lipid constituents of low density lipoprotein (LDL) were measured after sequential ultracentrifugation. Lipid peroxide levels in LDL were in the following order: LC > AS > H. Cholesteryl ester, triglycerides, free fatty acid, free cholesterol, and phospholipids were stained on plates of thin-layer chromatography of LDLs in healthy persons. However, spot X1 between triglycerides and free fatty acid was clearly colored on those of patients with atherosclerotic disease, and clear spot X2 between free fatty acid and free cholesterol, and a little spot X1 was stained on those of patients with lung cancer except for the lipid constituents mentioned above. No significant differences in lipid constituents were found among the patients with different histological types of lung cancer. Although lipid peroxide concentrations were significantly higher in the patients with lung cancer and artherosclerotic disease than in healthy persons, there were marked differences between patients with lung cancer and patients with artherosclelotic disease in the constituents of LDL lipid peroxide.
DOI：
10.1161/01.atv.3.4.283
发表时间：
1983
期刊：
Arteriosclerosis (Dallas, Tex.)
影响因子：
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作者：
Steinberg,D
通讯作者：
Steinberg,D