Enhanced thromboxane A2 biosynthesis in the kidney of spontaneously hypertensive rats during development of hypertension.
Enhanced thromboxane A2 biosynthesis in the kidney of spontaneously hypertensive rats during development of hypertension.
复制标题
高血压发展过程中自发性高血压大鼠肾脏中血栓素 A2 生物合成增强。
DOI：
10.1016/0014-2999(81)90157-6
复制
发表时间：
1981
影响因子：
5
通讯作者：
S. Kikuchi
中科院分区：
文献类型：
--
作者：
Y. Shibouta;Z. Terashita;Y. Inada;K. Nishikawa;S. Kikuchi
用6周龄和18周龄自发性高血压大鼠（SHR）、Wistar-Kyoto大鼠（WKY）、双肾大鼠（WKY）、离体肾脏灌流，观察花生四烯酸（AA）诱导的升压反应及TXA_2、前列腺素（PG）样物质（PLS）和前列环素（PGI_2）稳定代谢产物6-酮-PGF_（1 α）的产生。单夹高血压大鼠（RHR）和DOCA/盐高血压大鼠（DOCA/盐HR）。AA引起的升压反应和TXB_2的释放在6周龄SHR最高，而PLS和6-keto-PGF_（1 α）的释放在18周龄SHR和RHR和DOCA/salt HR的已建立的高血压阶段最显著。外源性TXA_2引起血管收缩，AA-1和AA-2之间呈正相关。引起升压反应和释放TXB 2或PLS。因此，自发性高血压的发生可能是由于AA释放刺激引起TXA_2和PGI_2合成加速所致。
Arachidonic acid (AA)-induced pressor response and production of thromboxane YXB2, the stable metabolite of TXA2, prostaglandin (PG)-like substance (PLS) and 6-keto-PGF1αthe stable metabolite of prostacyclin (PGI2), were studied using isolated, perfused kidneys of 6- and 18-week old spontaneously hypertensive rats (SHR), Wistar-Kyoto rats (WKY), two-kidney, one clip hpertensive rats (RHR) and DOCA/salt hypertensive rats (DOCA/salt HR). The AA-induced pressor response and release of TXB2were highest in the 6-week old SHR, whereas, the release of PLS and 6-keto-PGF1αwas marked in the 18-week old SHR and the established hypertensive stages of both RHR and DOCA/salt HR. In the kidneys of SHR and WKY, exogenous TXA2induced a severe vasoconstriction and there was a positive correlation between the AA-induced pressor response and the release of TXB2or PLS. Thus, the initiation of hypertension in SHR may follow an accelerated synthesis of TXA2against PGI2in response to stimuli which induce a release of AA.
前列腺素和肾脏。
影响因子：
4.2
作者：
Ferris,TF
通讯作者：
Ferris,TF