Enhanced drug delivery to cancer cells through a pH-sensitive polycarbonate platform.
Enhanced drug delivery to cancer cells through a pH-sensitive polycarbonate platform.
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DOI：
10.1039/d2bm01626e
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发表时间：
2023-01-31
影响因子：
6.6
通讯作者：
Dove, Andrew P. P.
中科院分区：
文献类型：
--
作者：
Arno, Maria C. C.;Simpson, Joshua D. D.;Blackman, Lewis D. D.;Brannigan, Ruairi P.;Thurecht, Kristofer J. J.;Dove, Andrew P. P.
聚合物-药物偶联物被广泛研究，以提高治疗药物对癌细胞的选择性，以及增加难溶性药物的循环寿命和溶解度。为了选择性地将这些结构导向癌细胞，靶向药物通常结合到纳米颗粒表面，以限制药物在非癌细胞中的积累，从而降低全身毒性。在这里，我们报告了一种简单的方法来生成可生物降解的聚碳酸酯接枝共聚物纳米颗粒，这种纳米颗粒允许高效的结合和细胞内释放S-(+)-喜树碱，一种广泛用于癌症治疗的拓扑异构酶I抑制剂。药物-聚合物缀合物在一系列非癌表型的癌细胞系中显示出很强的抑制细胞增殖的功效，这是由于细胞内积累增加和随后的药物释放，特别是在癌细胞中。体外对癌细胞的药物输送增强证明了该平台在不添加靶向配体的情况下进行选择性治疗的潜力。在本文中，我们报道了一种与抗癌药物喜树碱偶联的ph敏感聚碳酸酯，它显示出对癌细胞的药物传递增强。
Polymer–drug conjugates are widely investigated to enhance the selectivity of therapeutic drugs to cancer cells, as well as increase circulation lifetime and solubility of poorly soluble drugs. In order to direct these structures selectively to cancer cells, targeting agents are often conjugated to the nanoparticle surface as a strategy to limit drug accumulation in non-cancerous cells and therefore reduce systemic toxicity. Here, we report a simple procedure to generate biodegradable polycarbonate graft copolymer nanoparticles that allows for highly efficient conjugation and intracellular release of S-(+)-camptothecin, a topoisomerase I inhibitor widely used in cancer therapy. The drug–polymer conjugate showed strong efficacy in inhibiting cell proliferation across a range of cancer cell lines over non-cancerous phenotypes, as a consequence of the increased intracellular accumulation and subsequent drug release specifically in cancer cells. The enhanced drug delivery towards cancer cells in vitro demonstrates the potential of this platform for selective treatments without the addition of targeting ligands. In this paper we a report a pH-sensitive polycarbonate conjugated with the anticancer drug camptothecin that shows enhanced drug delivery towards cancer cells.
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影响因子：
9.7
作者：
Cajot, S.;Van Butsele, K.;Jerome, C.
通讯作者：
Jerome, C.
影响因子：
6.2
作者：
Arno, Maria C.;Brannigan, Ruairi P.;Dove, Andrew P.
通讯作者：
Dove, Andrew P.
影响因子：
6.2
作者：
Fuchs, Adrian V.;Tse, Brian W. C.;Thurecht, Kristofer J.
通讯作者：
Thurecht, Kristofer J.
影响因子：
8.6
作者：
Abbott, B. P.;Abbott, R.;Zweizig, J.
通讯作者：
Zweizig, J.
具有悬垂原酸酯的酸不稳定聚合物的简便合成
影响因子：
6.2
作者：
Cheng, Jing;Ji, Ran;Li, Zi-Chen
通讯作者：
Li, Zi-Chen