Role of the conformational rigidity in the design of biomimetic antimicrobial compounds.
Role of the conformational rigidity in the design of biomimetic antimicrobial compounds.
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DOI：
10.1002/anie.201003104
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发表时间：
2010-11-02
影响因子：
16.6
通讯作者：
Gidalevitz, David
中科院分区：
文献类型：
--
作者：
Ivankin, Andrey;Livne, Liran;Mor, Amram;Caputo, Gregory A.;DeGrado, William F.;Meron, Mati;Lin, Binhua;Gidalevitz, David
抗菌肽(AMP)是一种天然存在的抗生素，几乎存在于所有生物体中。[1]在过去的二十年里，AMP因其作为抗感染药物的潜在治疗用途而引起了人们的极大兴趣。然而，阻碍AMP进入医药市场的一些严重挑战包括它们在体内的快速降解、高昂的生产成本以及在生理条件下活性降低。[2]为了克服这些问题，同时保持多肽的天然抗感染特性，抗菌肽的非天然模拟物的领域迅速扩大。
Antimicrobial peptides (AMPs) are naturally occurring antibiotics found in essentially all living organisms.[1] In the past two decades, AMPs have attracted considerable interest because of their potential therapeutic use as anti-infective agents.[1, 2] There exists, however, a number of serious challenges preventing AMP from reaching a pharmaceutical market including their rapid in vivo degradation, high production costs, and reduced activity in physiological conditions.[2] Efforts to overcome these problems while retaining the peptides natural antiinfective properties resulted in the emergence of a rapidly expanding field of nonnatural mimics of antimicrobial peptides.
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影响因子：
3.4
作者：
Neville, Frances;Ishitsuka, Yuji;Gidalevitz, David
通讯作者：
Gidalevitz, David
影响因子：
3.4
作者：
Neville, F;Cahuzac, M;Gidalevitz, D
通讯作者：
Gidalevitz, D
影响因子：
15
作者：
Som, Abhigyan;Yang, Lihua;Wong, Gerard C. L.;Tew, Gregory N.
通讯作者：
Tew, Gregory N.
影响因子：
46.9
作者：
Radzishevsky, Inna S.;Rotem, Shahar;Mor, Amram
通讯作者：
Mor, Amram
影响因子：
3.3
作者：
Som, Abhigyan;Tew, Gregory N.
通讯作者：
Tew, Gregory N.