Harmonic acoustics for dynamic and selective particle manipulation.

Harmonic acoustics for dynamic and selective particle manipulation.
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DOI:
10.1038/s41563-022-01210-8
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发表时间:
2022-05
期刊:
影响因子:
41.2
通讯作者:
--
中科院分区:
材料科学1区
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--
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长期以来,胶体和生物细胞的精确和选择性操纵一直受到材料科学、物理和生命科学应用的推动。在这里,我们介绍了我们用于非接触式、动态、选择性(手)粒子操纵平台的谐声学,该平台能够通过以亚波长分辨率调制声波捕获位置来实现胶体晶体或细胞的可逆组装。我们合成傅立叶合成的谐波来创建软声学晶格和胶体晶体,而不需要进行表面处理或改变它们的材料性质。我们已经实现了对晶格常数的主动控制,以高通量(>100对)、精确、选择性和可逆的方式动态地调制粒子间的距离。此外,我们应用这个HANDS平台来量化不同癌细胞系之间的细胞间粘附力。我们的生物兼容Hands平台提供了一种高度通用的粒子操纵方法,可以处理软物质,并以高灵敏度测量活细胞之间的相互作用力。
Precise and selective manipulation of colloids and biological cells has long been motivated by applications in materials science, physics and the life sciences. Here we introduce our harmonic acoustics for a non-contact, dynamic, selective (HANDS) particle manipulation platform, which enables the reversible assembly of colloidal crystals or cells via the modulation of acoustic trapping positions with subwavelength resolution. We compose Fourier-synthesized harmonic waves to create soft acoustic lattices and colloidal crystals without using surface treatment or modifying their material properties. We have achieved active control of the lattice constant to dynamically modulate the interparticle distance in a high-throughput (>100 pairs), precise, selective and reversible manner. Furthermore, we apply this HANDS platform to quantify the intercellular adhesion forces among various cancer cell lines. Our biocompatible HANDS platform provides a highly versatile particle manipulation method that can handle soft matter and measure the interaction forces between living cells with high sensitivity.
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