The potential pathways underlying the association of propyl-paraben exposure with aeroallergen sensitization and EASI score using metabolomics analysis.
The potential pathways underlying the association of propyl-paraben exposure with aeroallergen sensitization and EASI score using metabolomics analysis.
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DOI：
10.1038/s41598-021-83288-9
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发表时间：
2021-02-12
影响因子：
4.6
通讯作者：
Han MY
中科院分区：
文献类型：
--
作者：
Lee Y;Lee E;Yon DK;Jee HM;Baek HS;Lee SW;Cho JY;Han MY
对羟基苯甲酸丙酯暴露与吸入性过敏原致敏相关，但其与特应性皮炎（AD）的相关性尚不确定。尚未对这些相关性的代谢组学途径进行研究。我们研究了对羟基苯甲酸丙酯暴露与空气过敏原致敏、AD和过敏面积和严重程度指数（EASI）评分之间的相关性，并使用非靶向代谢组学分析确定了潜在途径。我们在一项普通人群研究中招募了455名儿童。采用皮肤点刺试验，评估EASI评分。尿丙基，丁基，乙基和甲基-尼泊金水平进行了测量。对第一个和第五个尿液对羟基苯甲酸丙酯五分位数组进行非靶向代谢组学分析。最高尿丙-尼泊金五分位数组与空气过敏原致敏相关，但与AD无关。甘氨酸，苏氨酸，丝氨酸，鸟氨酸，异亮氨酸，阿拉伯呋喃糖，d-来苏呋喃糖，柠檬酸盐和吡啶甲酸水平较高，而棕榈酸和2-棕榈酰甘油水平较低，在最高的五分位数的丙-尼泊金酯组，比在最低的五分位数组。对羟基苯甲酸丙酯诱导的代谢紊乱与丝氨酸和甘氨酸代谢、支链氨基酸代谢和氨再循环相关。对羟基苯甲酸丙酯暴露与吸入过敏原致敏和EASI评分相关，部分通过与氧化应激、mTOR、过氧化物酶体增殖物激活受体途径、芳烃受体信号传导途径和三羧酸循环相关的代谢组学变化。
Propyl-paraben exposure is associated with aeroallergen sensitization, but its association with atopic dermatitis (AD) is inconclusive. No studies have been conducted on the metabolomic pathways underlying these associations. We investigated the associations between propyl-paraben exposure and aeroallergen sensitization, AD, and Eczema Area and Severity Index (EASI) score and identified the underlying pathways using untargeted metabolomics analysis. We enrolled 455 children in a general population study. Skin prick tests were performed with the assessment of EASI score. Urinary propyl-, butyl-, ethyl-, and methyl-paraben levels were measured. Untargeted metabolomics analysis was performed on the first and fifth urine propyl-paraben quintile groups. The highest urine propyl-paraben quintile group was associated with aeroallergen sensitization, but not with AD. Glycine, threonine, serine, ornithine, isoleucine, arabinofuranose, d-lyxofuranose, citrate, and picolinic acid levels were higher, whereas palmitic acid and 2-palmitoylglycerol levels were lower in the highest quintile propyl-paraben group, than in the lowest quintile group. The propyl-paraben-induced metabolic perturbations were associated with serine and glycine metabolisms, branched-chain amino acid metabolism, and ammonia recycling. Propyl-paraben exposure was associated with aeroallergen sensitization and EASI score, partially via metabolomic changes related with oxidative stress, mTOR, peroxisome proliferator-activated receptors pathway, aryl hydrocarbon receptor signaling pathways, and tricarboxylic acid cycle.
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影响因子：
14.2
作者：
Crestani, Elena;Harb, Hani;Chatila, Talal A.
通讯作者：
Chatila, Talal A.
DOI：
10.2174/1568010054526386
发表时间：
2005-08-01
期刊：
Current Drug Targets - Inflammation and Allergy
影响因子：
--
作者：
Okayama, Yoshimichi
通讯作者：
Okayama, Yoshimichi
影响因子：
14.2
作者：
Ding, Xiaolei;Willenborg, Sebastian;Eming, Sabine A.
通讯作者：
Eming, Sabine A.
影响因子：
7.4
作者：
Nikolskiy, Igor;Mahieu, Nathaniel G.;Chen, Ying-Jr;Tautenhahn, Ralf;Patti, Gary J.
通讯作者：
Patti, Gary J.
DOI：
10.4168/aair.2018.10.3.207
发表时间：
2018-05
期刊：
Allergy, asthma & immunology research
影响因子：
--
作者：
Kim BE;Leung DYM
通讯作者：
Leung DYM