Investigation of the efficacy and safety of retinal inactivation as a treatment for amblyopia in cats.
Investigation of the efficacy and safety of retinal inactivation as a treatment for amblyopia in cats.
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DOI：
10.3389/fnins.2023.1167007
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发表时间：
2023
影响因子：
4.3
通讯作者：
Duffy, Kevin R.
中科院分区：
文献类型：
--
作者：
Hogan, Mairin;DiCostanzo, Nadia R.;Crowder, Nathan A.;Fong, Ming-fai;Duffy, Kevin R.
关键词：
在出生后发育的早期，正常视力的丧失会导致主要视觉通路内的神经回路的改变，这可能导致严重且难治性的视力障碍（弱视）。在猫中，弱视通常以单眼剥夺（MD）为模型，这是一种涉及暂时关闭一只眼睛的眼睑的程序。在长期MD之后，优势眼视网膜的短暂失活可以促进从MD的解剖学和生理学影响中恢复。考虑到视网膜失活作为一种可行的弱视治疗方法，必须将其疗效与常规治疗进行比较，并评估其给药的安全性。在当前的研究中，我们比较了视网膜失活和主眼阻塞（反向阻塞）的各自功效，以引起猫从先前长期MD的生理恢复。由于形觉剥夺与近视的发展有关，我们还检查了视网膜失活一段时间是否会改变眼轴长度或屈光不正。本研究的结果表明，一段时间的MD后，失活的优势眼长达10天引起视觉诱发电位的显着恢复，这是上级恢复后测量的反向闭塞相当的持续时间。单眼视网膜失活后，眼轴长度和屈光不正的测量值从失活前的值没有显著改变。在灭活期间，体重增加率也未发生变化，表明总体健康状况未受到影响。这些结果提供的证据表明，失活的优势眼后一段时间的弱视饲养促进更好的恢复比眼睛闭塞，而这种恢复是在没有形觉剥夺性近视的发展。
Deprivation of normal vision early in postnatal development elicits modifications of neural circuitry within the primary visual pathway that can cause a severe and intractable vision impairment (amblyopia). In cats, amblyopia is often modeled with monocular deprivation (MD), a procedure that involves temporarily closing the lids of one eye. Following long-term MD, brief inactivation of the dominant eye’s retina can promote recovery from the anatomical and physiological effects of MD. In consideration of retinal inactivation as a viable treatment for amblyopia it is imperative to compare its efficacy against conventional therapy, as well as assess the safety of its administration. In the current study we compared the respective efficacies of retinal inactivation and occlusion of the dominant eye (reverse occlusion) to elicit physiological recovery from a prior long-term MD in cats. Because deprivation of form vision has been associated with development of myopia, we also examined whether ocular axial length or refractive error were altered by a period of retinal inactivation. The results of this study demonstrate that after a period of MD, inactivation of the dominant eye for up to 10 days elicited significant recovery of visually-evoked potentials that was superior to the recovery measured after a comparable duration of reverse occlusion. After monocular retinal inactivation, measurements of ocular axial length and refractive error were not significantly altered from their pre-inactivation values. The rate of body weight gain also was not changed during the period of inactivation, indicating that general well-being was not affected. These results provide evidence that inactivation of the dominant eye after a period of amblyogenic rearing promotes better recovery than eye occlusion, and this recovery was achieved without development of form-deprivation myopia.
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影响因子：
9.2
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