Proton pump inhibitors and sensitization of cancer cells to radiation therapy.
Proton pump inhibitors and sensitization of cancer cells to radiation therapy.
复制标题
DOI：
10.3389/fonc.2022.937166
复制
发表时间：
2022
影响因子：
4.7
通讯作者：
Ghebre, Yohannes T.
中科院分区：
文献类型：
--
作者：
Hebert, Kassidy A.;Bonnen, Mark D.;Ghebre, Yohannes T.
这篇综述文章概述了六种分子途径，赋予癌细胞电离辐射的抗性，并介绍了质子泵抑制剂（PPI）如何可用于克服辐射抗性诱导的一个或多个这些信号通路的改变。炎症、适应性、缺氧、DNA损伤修复、细胞粘附和发育途径都与癌细胞对电离辐射的抗性有关。在这里，我们描述了癌细胞中这些途径的改变与电离辐射抗性的发展之间的分子联系，并讨论了使用PPI有利地修饰这些途径的一种或多种组分以使癌细胞对电离辐射敏感的新兴数据。了解改变的信号通路、放射抗性和PPI的生物活性之间的关系可以作为重新利用PPI的基础，以恢复参与癌症进展的关键生物过程，并使癌细胞对放射治疗敏感。
This review article outlines six molecular pathways that confer resistance of cancer cells to ionizing radiation, and describes how proton pump inhibitors (PPIs) may be used to overcome radioresistance induced by alteration of one or more of these signaling pathways. The inflammatory, adaptive, hypoxia, DNA damage repair, cell adhesion, and developmental pathways have all been linked to the resistance of cancer cells to ionizing radiation. Here we describe the molecular link between alteration of these pathways in cancer cells and development of resistance to ionizing radiation, and discuss emerging data on the use of PPIs to favorably modify one or more components of these pathways to sensitize cancer cells to ionizing radiation. Understanding the relationship between altered signaling pathways, radioresistance, and biological activity of PPIs may serve as a basis to repurpose PPIs to restore key biological processes that are involved in cancer progression and to sensitize cancer cells to radiation therapy.
登录
查看更多内容
影响因子：
6.2
作者：
Delaney, G;Jacob, S;Barton, M
通讯作者：
Barton, M
影响因子：
3.6
作者：
Baskar R;Lee KA;Yeo R;Yeoh KW
通讯作者：
Yeoh KW
影响因子：
5.6
作者：
Cascio, Sandra;Ferla, Rita;Russo, Antonio
通讯作者：
Russo, Antonio
影响因子：
50.5
作者：
Chalabi, M.;Cardona, A.;Herrera, F. G.
通讯作者：
Herrera, F. G.
DOI：
10.1634/theoncologist.2017-0474
发表时间：
2018-01
期刊：
The oncologist
影响因子：
--
作者：
Araujo-Mino EP;Patt YZ;Murray-Krezan C;Hanson JA;Bansal P;Liem BJ;Rajput A;Fekrazad MH;Heywood G;Lee FC
通讯作者：
Lee FC