A dedicated breast-PET/CT scanner: Numerical observer study of lesion detection.
A dedicated breast-PET/CT scanner: Numerical observer study of lesion detection.
复制标题
专用的胸胸/CT扫描仪：病变检测的数值观察者研究。
DOI：
10.1002/mp.16033
复制
发表时间：
2022-12
期刊：
影响因子：
3.8
通讯作者：
Roemer, Kathryn
中科院分区：
文献类型：
--
作者：
Raylman, Raymond R.;Stolin, Alexander;Hays, Savannah;Johnson, Evan;Lankas, Sarah;Mekonnen, Mahder;Roemer, Kathryn
专门的乳房专用正电子发射断层扫描(BPET)-锥束计算机断层扫描(BPET/CT)系统已经被开发出来，以改进对因辐射乳房而导致的乳房X光检查不确定的妇女的癌症的检测和诊断。在这一组女性中，X射线的吸收经常困扰着乳房X光检查，但这并不影响对PET中使用的高能湮没光子的检测。然而，乳腺的PET成像由于其相对较低的空间分辨率(~2 mm)以及病变中的中等放射性示踪剂摄取而受到限制。这项研究的目的是探索西弗吉尼亚大学放射仪器系开发的BPET/CT扫描仪基于PET的病变检测能力。该系统的PET组件由一对96×72个2×2×15 mm~3的LYSO闪烁体元件的旋转对组成。锥束CT组件利用脉冲X射线源和垂直方向工作的平板探测器。CT扫描仪生成的密度图用于校正BPET数据中的光子衰减和康普顿散射。在一个特殊设计的体模中模拟了正常乳腺组织对18F-脱氧葡萄糖(FDG)的不均匀摄取，该体模由一个填充了丙烯酸珠子和含有FDG的液体的丙烯酸圆柱体组成。用含有不同量FDG的琼脂小球(直径分别为3 mm、4 mm、6 mm、8 mm和10 mm)模拟FDG阳性病变，以产生6：1、8：1和10：1的靶-本底比(TBR)。这些小球还含有X射线造影剂，即使是最小的也能在CT图像上容易看到。所有病变的位置均在CT图像上明确。这些位置被用来从PET图像中提取信号存在和信号缺失的子图像。然后将子图像输入到软件中，该软件计算了两个数值模式观察者(Laguerre-Gauss信道化Hotling(LG-CHO)和非预白化匹配滤波器(NPWMF))的曲线下面积(AUC)。结果表明，该系统可检测到的最小病变直径不小于约3 mm，TBR为6：1。计算直径为4 mm或更大的模拟病变对所有测试的TBR具有良好的或极好的检测可能性。这项调查的结果确定了专用乳腺PET/CT扫描仪的检测能力和局限性。它能够检测相对较小的模拟FDG狂热乳腺病变的一系列TBR表明其潜在的临床应用。最后，这项研究使用了可以应用于其他PET/CT扫描仪的可检测性评估的方法。
Dedicated, breast-specific Positron Emission Tomography (BPET)-Cone Beam Computed Tomography (BPET/CT) systems have been developed to improve detection and diagnosis of cancer in women with indeterminate mammograms caused by radiodense breasts. The absorption of x-rays that often vexes mammography in this subset of women does not affect detection of the high energy annihilation photons used in PET. PET imaging of the breast, however, is subject to limitations caused by their comparatively low spatial resolution (~2mm) and often moderate radiotracer uptake in lesions. The purpose of this investigation is to explore the PET-based lesion detection capabilities of a BPET/CT scanner developed by the Department of Radiology Instrumentation group at West Virginia University. The PET component of the system consists of a rotating pair of 96×72 arrays of 2×2×15mm3 LYSO scintillator elements. The cone beam-CT component utilized a pulsed x-ray source and flat panel detector operated in portrait orientation. The density maps created by the CT scanner were used to correct the BPET data for photon attenuation and Compton scattering. The non-uniform uptake of 18F-Fluorodeoxyglucose (FDG) in normal breast tissue was emulated in a specially designed phantom consisting of an acrylic cylinder filled with a mixture of acrylic beads and liquid containing FDG. FDG-avid lesions were simulated with agar spheres (3mm, 4mm, 6mm, 8mm and 10mm diameters) containing vary amounts of FDG to produce target-to-background ratios (TBR) of 6:1, 8:1 and 10:1. The spheres also contained x-ray contrast agent to make even the smallest ones readily visible in CT images. Positions of all the lesions were identified in the CT images. These positions were used to extract signal present and signal absent sub-images from the PET images. The sub-images were then input to software that calculated areas-under-the-curve (AUC) for two numerical model observers (Laguerre-Gauss Channelized Hotelling (LG-CHO) and non-prewhitening matched filter (NPWMF)). The results showed that the smallest detectable lesion with this system is no smaller than approximately 3mm in diameter with a TBR of 6:1. Simulated lesions with diameters of 4mm and greater were calculated to have good to excellent likelihood of detection for all TBRs tested. The results from this investigation identified the detectability capabilities and limitations for a dedicated breast PET/CT scanner. Its ability to detect relatively small simulated FDG-avid breast lesions for a range of TBRs indicates its potential for clinical application. Finally, the study used methodologies that could be applied to detectability assessment of other PET/CT scanners.
登录
查看更多内容
DOI：
10.1073/pnas.90.21.9758
发表时间：
1993-11-01
影响因子：
11.1
作者：
BARRETT, HH;YAO, J;MYERS, KJ
通讯作者：
MYERS, KJ
影响因子：
19.7
作者：
Kolb, TM;Lichy, J;Newhouse, JH
通讯作者：
Newhouse, JH
影响因子：
19.7
作者：
JACKSON, VP;HENDRICK, RE;KOPANS, DB
通讯作者：
KOPANS, DB
影响因子：
3.5
作者：
Godinez F;Chaudhari AJ;Yang Y;Farrell R;Badawi RD
通讯作者：
Badawi RD
影响因子：
10.3
作者：
Buist, DSM;Porter, PL;White, E
通讯作者：
White, E