Associations in asthma between quantitative computed tomography and bronchial biopsy-derived airway remodelling.
Associations in asthma between quantitative computed tomography and bronchial biopsy-derived airway remodelling.
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DOI：
10.1183/13993003.01507-2016
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发表时间：
2017-05
期刊：
影响因子：
--
通讯作者：
Brightling CE
中科院分区：
文献类型：
--
作者：
Berair R;Hartley R;Mistry V;Sheshadri A;Gupta S;Singapuri A;Gonem S;Marshall RP;Sousa AR;Shikotra A;Kay R;Wardlaw A;Bradding P;Siddiqui S;Castro M;Brightling CE
哮喘中的气道重塑仍然知之甚少。本研究旨在确定支气管活检测量的气道重塑与 i) 肺功能损伤和 ii) 定量胸部 CT (QCT) 衍生的近端气道重塑和空气滞留的形态测量和密度测量之间的关联。从单中心招募受试者。支气管活检重塑特征是肺功能损伤的最强预测因素，并且通过逐步多元回归确定 QCT 衍生的近端气道形态测量和空气滞留标记。空气滞留的最佳预测因子在独立的复制组中得到了验证。气道平滑肌百分比 (ASM %) 是支气管扩张剂后 FEV1 % 预测的唯一预测因子，而 ASM % 和血管分布都是 FEV1/FVC 的预测因子。上皮厚度和 ASM % 是平均节段支气管管腔面积的预测因子（R2=0.12；p=0.02 和 R2=0.12；p=0.015）。而上皮厚度是壁面积百分比的唯一预测因子（R2=0.13；p=0.018）。血管分布是空气滞留的唯一显着预测因子（R2=0.24；p=0.001），这在复制组中得到了验证（R2=0.19；p=0.031）。在哮喘中，气道平滑肌含量和血管分布均与气流阻塞有关。 QCT 衍生的近端气道形态测量与上皮厚度和气道平滑肌含量密切相关，而空气滞留则与血管分布相关。
Airway remodelling in asthma remains poorly understood. This study aimed to determine the association of airway remodelling measured on bronchial biopsies with i) lung function impairment and ii) quantitative thoracic CT (QCT)-derived morphometry and densitometry measures of proximal airway remodelling and air-trapping. Subjects were recruited from a single centre Bronchial biopsy remodelling features that were the strongest predictors of lung function impairment and QCT-derived proximal airway morphometry and air-trapping markers were determined by step-wise multiple regression. The best predictor of air-trapping was validated in an independent replication group. Airway smooth muscle percentage (ASM %) was the only predictor of post-bronchodilator FEV1 % predicted, while both ASM % and vascularity were predictors of FEV1/FVC. Epithelial thickness and ASM % were predictors of mean segmental bronchial luminal area (R2=0.12; p=0.02 and R2=0.12; p=0.015). Whereas epithelial thickness was the only predictor of % wall area (R2=0.13; p=0.018). Vascularity was the only significant predictor of air-trapping (R2=0.24; p=0.001), which was validated in the replication group (R2=0.19; p=0.031). In asthma, airway smooth muscle content and vascularity were both associated with airflow obstruction. QCT-derived proximal airway morphometry was most strongly associated with epithelial thickness and airway smooth muscle content, whereas air-trapping was related to vascularity.
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哮喘和慢性阻塞性肺部疾病患者的气道重塑，空气捕获和肺气肿的定量计算机断层扫描参数之间的关系：一项单中心研究。
DOI：
10.1016/j.jaci.2016.02.001
发表时间：
2016-05
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Hartley RA;Barker BL;Newby C;Pakkal M;Baldi S;Kajekar R;Kay R;Laurencin M;Marshall RP;Sousa AR;Parmar H;Siddiqui S;Gupta S;Brightling CE
通讯作者：
Brightling CE
影响因子：
24.3
作者：
Chung, Kian Fan;Wenzel, Sally E.;Teague, W. Gerald
通讯作者：
Teague, W. Gerald
DOI：
10.1056/nejmoa0808991
发表时间：
2009-03-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Haldar P;Brightling CE;Hargadon B;Gupta S;Monteiro W;Sousa A;Marshall RP;Bradding P;Green RH;Wardlaw AJ;Pavord ID
通讯作者：
Pavord ID
影响因子：
158.5
作者：
Brightling, CE;Bradding, P;Pavord, ID
通讯作者：
Pavord, ID
影响因子：
10
作者：
Du Rand, I. A.;Blaikley, J.;Munavvar, M.
通讯作者：
Munavvar, M.