Effect of Shenxinning decoction on ventricular remodeling in AT1 receptor-knockout mice with chronic renal insufficiency.
Effect of Shenxinning decoction on ventricular remodeling in AT1 receptor-knockout mice with chronic renal insufficiency.
复制标题
肾心宁汤对AT1受体敲除慢性肾功能不全小鼠心室重构的影响
DOI：
10.4103/0253-7613.135950
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发表时间：
2014-07
影响因子：
2.4
通讯作者：
He L
中科院分区：
文献类型：
--
作者：
Yang X;Zhou H;Qu H;Liu W;Huang X;Shun Y;He L
目的：观察参心宁汤（SXND）对慢性肾功能不全（CRI） AT1受体敲除（AT1- ko）小鼠心室重构的影响。材料与方法：采用肾大部切除（5/6）的AT1-KO小鼠模型，给予SXND干预12周。随后，将AT1-KO小鼠的血尿素氮（BUN）、血清肌酐（SCr）、脑利钠肽（BNP）、超声心动图(左心室舒张末期内径（LVDD）、左心室收缩末期内径（LVDS）、缩短分数（FS）、射血分数（EF）、心脏和肾脏I型和III型胶原蛋白、心肌线粒体、心脏转化生长因子-β1 （TGF-β1）与单纯肾切除和未治疗SXND的同一模型进行比较。结果：AT1-KO对小鼠心肌缺血再灌注过程无明显影响，但对心脏重构过程有明显影响。SXND可在一定程度上降低AT1-KO小鼠的BUN、SCr、BNP及心脏LVDD、LVDS、BNP，改善FS和EF，降低心脏和肾脏I型和III型胶原的表达，增加线粒体数量并改善其结构，下调TGF-β1的表达。结论：SXND可拮抗肾素-血管紧张素系统（RAS），减少尿毒症毒素，从而改善CRI心室重构。此外，SXND与心肌能量代谢改善、TGF-β1下调存在相关机制。
Objective: To observe the efficacy of Shenxinning Decoction (SXND) in ventricular remodeling in AT1 receptor-knockout (AT1-KO) mice with chronic renal insufficiency (CRI). Materials and Methods: AT1-KO mice modeled with subtotal (5/6) nephrectomy were intervened with SXND for 12 weeks. Subsequently, blood urea nitrogen (BUN), serum creatinine (SCr), brain natriuretic peptide (BNP), echocardiography (left ventricular end-diastolic diameter, LVDD; left ventricular end-systolic diameter, LVDS; fractional shortening, FS; and ejection fraction, EF), collagen types I and III in the heart and kidney, myocardial mitochondria, and cardiac transforming growth factor-β1 (TGF-β1) of the AT1-KO mice were compared with the same model with nephrectomy only and untreated with SXND. Results: AT1-KO mice did not affect the process of CRI but it could significantly affect cardiac remodeling process. SXND decreased to some extent the AT1-KO mice's BUN, SCr, BNP, and cardiac LVDD, LVDS, and BNP, improved FS and EF, lowered the expression of collagen type I and III in heart and kidney, increased the quantity of mitochondria and ameliorated their structure, and down-regulated the expression of TGF-β1. Conclusion: SXND may antagonize the renin–angiotensin system (RAS) and decrease uremia toxins, thereby ameliorating ventricular remodeling in CRI. Furthermore, SXND has a mechanism correlated with the improvement of myocardial energy metabolism and the down-regulation of TGF-β1.
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影响因子：
20.1
作者：
Mercure, Chantal;Yogi, Alvaro;Reudelhuber, Timothy L.
通讯作者：
Reudelhuber, Timothy L.
影响因子：
8.3
作者：
Laviades, C;Varo, N;Díez, J
通讯作者：
Díez, J
影响因子：
3.5
作者：
Jin, Denan;Takai, Shinji;Miyazaki, Mizuo
通讯作者：
Miyazaki, Mizuo
冠状动脉疾病合并高同型半胱氨酸血症患者血清硫氧还蛋白水平降低与疾病严重程度密切相关
影响因子：
5.3
作者：
Wu, Yunfei;Yang, Lijuan;Zhong, Liangwei
通讯作者：
Zhong, Liangwei
DOI：
10.1159/000313718
发表时间：
2010-01-01
期刊：
FLUID OVERLOAD: DIAGNOSIS AND MANAGEMENT
影响因子：
--
作者：
Ronco, Claudio
通讯作者：
Ronco, Claudio