Ets-1 and Ets-2 proto-oncogenes exhibit differential and restricted expression patterns during Xenopus laevis oogenesis and embryogenesis.
Ets-1 and Ets-2 proto-oncogenes exhibit differential and restricted expression patterns during Xenopus laevis oogenesis and embryogenesis.
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Ets-1 和 Ets-2 原癌基因在非洲爪蟾卵子发生和胚胎发生过程中表现出差异性和限制性表达模式。
DOI：
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发表时间：
1997
影响因子：
0.7
通讯作者：
Par Julien Remy
中科院分区：
文献类型：
--
作者：
David E. Meyer;Marcel Durliat;F. Senan;Michael W. Wolff;Michèle André;J. Hourdry;Par Julien Remy
非洲爪蟾 XI-ets-1 和 XI-ets-2 是母系表达的。从卵子发生晚期到胚胎发生早期，它们的转录物定位于动物极和中间区，表明在动物卵裂球和未来中胚层的分化中具有功能。它们在种质水平的存在表明它们在生发谱系的分化中也发挥着作用。两个合子基因从 MBT 开始普遍表达，然后限制在胚孔周围。在神经胚和尾芽阶段，在神经嵴细胞及其衍生物中检测到 ets-1 和 ets-2 转录本。还可以在成血管细胞前体、形成心脏和血管的内皮细胞中观察到 ets-1 的特异性转录。 Ets-2本身在假定的前肾以及形成的前肾小管和延伸的前肾管中特异性表达。与 ets-gene 家族 (XI-fli) 的另一个成员一样，这两个基因都在经历重要形态发生修饰的胚胎区域转录，特别是在迁移细胞中和/或沿其迁移途径。我们假设这些基因协调细胞粘附的修饰。钙粘蛋白和整合素库表达的变化与这种作用一致，并且可以解释我们之前报道的 XI-fli 过度表达的表型。除了已经归因于 ets-1 在细胞外基质特异性蛋白酶表达中的作用之外，这种作用对于肿瘤细胞传播也至关重要。
Xenopus XI-ets-1 and XI-ets-2 are maternally expressed. From late oogenesis to early embryogenesis their transcripts are localized to the animal pole and the intermediate zone, suggesting a function in the differentiation of animal blastomeres and future mesoderm. Their presence at the level of germ plasm suggests also a role in the differentiation of the germinal lineage. Both zygotic genes are expressed ubiquitously beginning at MBT, and then restricted to a circumblastoporal collar. In neurula and tailbud stages, ets-1 and ets-2 transcripts are detected in neural crest cells and their derivatives. Specific transcription can also be observed for ets-1 in the hemangioblastic precursors, in endothelial cells of the forming heart and blood vessels. Ets-2 is itself specifically expressed in the putative pronephros and in the forming pronephric tubules and extending pronephric duct. Like another member of the ets-gene family (XI-fli), both genes are transcribed in regions of the embryo undergoing important morphogenetic modifications, especially in migrating cells and/or along their migration pathways. We postulate that these genes orchestrate modifications of cellular adhesion. Changes in the expression of cadherins and integrins repertories would be consistent with such a role and could account for the phenotypes we reported earlier for XI-fli overexpression. Such a role would be critical for tumor cell dissemination, in addition to the one already ascribed to ets-1 in the expression of proteases specific for the extracellular matrix.
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影响因子：
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作者：
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通讯作者：
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作者：
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作者：
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DOI：
10.1073/pnas.89.20.9934
发表时间：
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影响因子：
11.1
作者：
Prosser,HM;Wotton,D;Gegonne,A;Ghysdael,J;Wang,S;Speck,NA;Owen,MJ
通讯作者：
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DOI：
10.1242/dev.119.4.991
发表时间：
1993
期刊：
Development (Cambridge, England)
影响因子：
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作者：
Gont,LK;Steinbeisser,H;Blumberg,B;deRobertis,EM
通讯作者：
deRobertis,EM