Tailored covalently cross-linked hydrogels based on oxidized cellulose sulfate and carboxymethyl chitosan by targeted adjustment of the storage modulus

Tailored covalently cross-linked hydrogels based on oxidized cellulose sulfate and carboxymethyl chitosan by targeted adjustment of the storage modulus
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通过有针对性地调整储能模量,定制基于氧化纤维素硫酸盐和羧甲基壳聚糖的共价交联水凝胶

DOI:
10.1007/s10570-020-03279-3
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发表时间:
2020
期刊:
影响因子:
5.7
通讯作者:
S. Fischer
S. Fischer
中科院分区:
材料科学2区
文献类型:
--
作者:
J. Strätz;S. Fischer

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通常,水凝胶合成在创建新的水凝胶时使用试错法,然后搜索接收到的水凝胶的合适应用。一种更有效和可持续的方法是在开始有针对性地合成具有特定性质的水凝胶之前考虑到应用。因此,本研究的目的是研究以氧化纤维素硫酸盐和羧甲基壳聚糖为基础的共价交联水凝胶的存储模数的影响因素--以取代度、质量平均相对分子质量、混合比和凝胶化时间表示的交联度。结果表明:增大质量平均相对分子质量和交联度,并使混合比向决定水凝胶中可能的交联度的聚合物方向移动,可获得较高的F值。这项工作的结果可能被转移到类似的系统,并有助于有针对性地合成具有特定特性的水凝胶。
In general hydrogel synthesis uses a trial and error method when creating new hydrogels and searches afterwards for a fitting application of the received hydrogel. A much more effective and sustainable approach would be to have an application in mind before starting a targeted synthesis of a hydrogel with specific properties. Hence the goal of the study is to investigate influencing factors—crosslink density here represented through the degree of substitution, mass average molecular mass, mixing ratio and time for gelation—to the storage modulusfor covalently cross-linked hydrogels based on oxidized cellulose sulfate and carboxymethyl chitosan. The results can be summarized as follows: higher values forcan be reached by increasing the mass average molecular mass, the crosslink density and by shifting the mixing ratio toward the polymer which determines the number of possible cross-linkings in the hydrogel. The findings of this work may be transferred to similar systems and are helpful for a targeted synthesis of hydrogels with specific characteristics.
使用化学方法进行基因传递
DOI: --
发表时间: 2011
期刊:
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DOI: 10.1002/actp.1992.010430505
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