Metabolic reprogramming: a bridge between aging and tumorigenesis.
Metabolic reprogramming: a bridge between aging and tumorigenesis.
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代谢重编程：衰老与肿瘤发生之间的桥梁。
DOI：
10.1002/1878-0261.13261
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发表时间：
2022-09
影响因子：
6.6
通讯作者：
Gomes, Ana P.
中科院分区：
文献类型：
--
作者：
Drapela, Stanislav;Ilter, Didem;Gomes, Ana P.
衰老是癌症发生的最重要的危险因素，超过 60% 的癌症发生在 60 岁及以上的人群中。然而，人们对衰老和肿瘤发生如何交织在一起知之甚少，并且是一个存在重大争议的问题。代谢变化是衰老和肿瘤发生的标志。衰老的有害后果包括细胞过程功能失调、循环和组织内代谢副产物和废物分子的积累，以及阻碍血液流动和氧合的结缔组织变硬。总的来说，这些年龄驱动的变化导致特定组织的不同细胞类型发生代谢重编程，从而显着影响其细胞功能。在这里，我们提出了这样的观点：衰老过程中发生的代谢变化有助于为肿瘤发生创造有利的环境。我们回顾了衰老过程中发生的代谢变化的相似之处，以及这些变化如何发挥作用，既作为使恶性表型以细胞自主方式发展的适应性机制，又作为抑制免疫监视的机制，共同为癌症的生长创造了完美的环境。因此，针对随着年龄增长而发生的代谢重编程的抗衰老治疗策略可能会提供新的机会来预防癌症发生和/或改善对标准护理抗癌疗法的反应。致瘤性和免疫功能与宿主的代谢状态有关。随着生物体衰老，新陈代谢的变化，包括营养感应、细胞能量学和氧化还原平衡的变化，产生了有利于肿瘤发生的环境。因此，促进代谢恢复活力的策略可能会预防与年龄相关的肿瘤发生并增强抗癌治疗的有效性。
Aging is the most robust risk factor for cancer development, with more than 60% of cancers occurring in those aged 60 and above. However, how aging and tumorigenesis are intertwined is poorly understood and a matter of significant debate. Metabolic changes are hallmarks of both aging and tumorigenesis. The deleterious consequences of aging include dysfunctional cellular processes, the build‐up of metabolic byproducts and waste molecules in circulation and within tissues, and stiffer connective tissues that impede blood flow and oxygenation. Collectively, these age‐driven changes lead to metabolic reprogramming in different cell types of a given tissue that significantly affects their cellular functions. Here, we put forward the idea that metabolic changes that happen during aging help create a favorable environment for tumorigenesis. We review parallels in metabolic changes that happen during aging and how these changes function both as adaptive mechanisms that enable the development of malignant phenotypes in a cell‐autonomous manner and as mechanisms that suppress immune surveillance, collectively creating the perfect environment for cancers to thrive. Hence, antiaging therapeutic strategies that target the metabolic reprogramming that occurs as we age might provide new opportunities to prevent cancer initiation and/or improve responses to standard‐of‐care anticancer therapies. Tumorigenicity and immune function are linked to the metabolic status of the host. As an organism ages, changes in metabolism, including changes in nutrient sensing, cellular energetics, and redox balance, produce an environment conducive to tumor initiation. Thus, strategies that promote metabolic rejuvenation might prevent age‐related tumor initiation and enhance the effectiveness of anticancer therapies.
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影响因子：
8.8
作者：
Brown K;Xie S;Qiu X;Mohrin M;Shin J;Liu Y;Zhang D;Scadden DT;Chen D
通讯作者：
Chen D
DOI：
10.1016/0921-8734(92)90020-p
发表时间：
1992-09-01
期刊：
MUTATION RESEARCH
影响因子：
--
作者：
ARNHEIM, N;CORTOPASSI, G
通讯作者：
CORTOPASSI, G
影响因子：
29
作者：
Chatterjee S;Daenthanasanmak A;Chakraborty P;Wyatt MW;Dhar P;Selvam SP;Fu J;Zhang J;Nguyen H;Kang I;Toth K;Al-Homrani M;Husain M;Beeson G;Ball L;Helke K;Husain S;Garrett-Mayer E;Hardiman G;Mehrotra M;Nishimura MI;Beeson CC;Bupp MG;Wu J;Ogretmen B;Paulos CM;Rathmell J;Yu XZ;Mehrotra S
通讯作者：
Mehrotra S
影响因子：
3.9
作者：
CEDERGREN, R;GRAY, MW;SANKOFF, D
通讯作者：
SANKOFF, D
影响因子：
29
作者：
Bjedov I;Toivonen JM;Kerr F;Slack C;Jacobson J;Foley A;Partridge L
通讯作者：
Partridge L