Spatially selective depletion of tumor-associated regulatory T cells with near-infrared photoimmunotherapy.
Spatially selective depletion of tumor-associated regulatory T cells with near-infrared photoimmunotherapy.
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DOI：
10.1126/scitranslmed.aaf6843
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发表时间：
2016-08-17
影响因子：
17.1
通讯作者：
Kobayashi H
中科院分区：
文献类型：
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作者：
Sato K;Sato N;Xu B;Nakamura Y;Nagaya T;Choyke PL;Hasegawa Y;Kobayashi H
目前的癌症免疫疗法寻求调节不同免疫细胞群之间的平衡，从而促进抗肿瘤免疫反应。然而，由于这些是全身疗法，它们常常会导致治疗限制性自身免疫不良反应。在不扰乱身体其他部位的稳态的情况下操纵肿瘤内抑制细胞和效应细胞之间的平衡将是理想的。 CD4+CD25+Foxp3+调节性T细胞（Treg）是众所周知的免疫抑制细胞，在肿瘤免疫逃避中发挥关键作用，一直是全身免疫治疗的靶点。我们使用CD25靶向近红外光免疫疗法（NIR-PIT）选择性地消耗Tregs，从而激活CD8 T和自然杀伤细胞，恢复局部抗肿瘤免疫。这不仅导致治疗的肿瘤消退，而且还诱导相同细胞系衍生的单独的未治疗肿瘤的反应。我们得出的结论是，靶向 CD25 的 NIR-PIT 会导致 Tregs 的空间选择性耗竭，从而为癌症免疫治疗提供了另一种方法。
Current immunotherapies for cancer seek to modulate the balance among different immune cell populations, thereby promoting antitumor immune responses. However, because these are systemic therapies, they often cause treatment-limiting autoimmune adverse effects. It would be ideal to manipulate the balance between suppressor and effector cells within the tumor without disturbing homeostasis elsewhere in the body. CD4+CD25+Foxp3+ regulatory T cells (Tregs) are well-known immunosuppressor cells that play a key role in tumor immunoevasion and have been the target of systemic immunotherapies. We used CD25-targeted near-infrared photoimmunotherapy (NIR-PIT) to selectively deplete Tregs, thus activating CD8 T and natural killer cells and restoring local antitumor immunity. This not only resulted in regression of the treated tumor but also induced responses in separate untreated tumors of the same cell line derivation. We conclude that CD25-targeted NIR-PIT causes spatially selective depletion of Tregs, thereby providing an alternative approach to cancer immunotherapy.
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影响因子：
9.7
作者：
Sato K;Nagaya T;Mitsunaga M;Choyke PL;Kobayashi H
通讯作者：
Kobayashi H
用激动性抗GITR mAb治疗晚期肿瘤及其对肿瘤浸润Foxp3+CD25+CD4+调节T细胞的影响。
影响因子：
15.3
作者：
Ko, K;Yamazaki, S;Nakamura, K;Nishioka, T;Hirota, K;Yamaguchi, T;Shimizu, J;Nomura, T;Chiba, T;Sakaguchi, S
通讯作者：
Sakaguchi, S
DOI：
10.1084/jem.20130762
发表时间：
2013-10-21
期刊：
The Journal of experimental medicine
影响因子：
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作者：
Bos PD;Plitas G;Rudra D;Lee SY;Rudensky AY
通讯作者：
Rudensky AY
影响因子：
5.7
作者：
Sato K;Hanaoka H;Watanabe R;Nakajima T;Choyke PL;Kobayashi H
通讯作者：
Kobayashi H
影响因子：
82.9
作者：
通讯作者：
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