Low radiation dose in computed tomography: the role of iodine.
Low radiation dose in computed tomography: the role of iodine.
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DOI：
10.1259/bjr.20170079
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Albrecht T
中科院分区：
文献类型：
--
作者：
Aschoff AJ;Catalano C;Kirchin MA;Krix M;Albrecht T
最近的方法，以减少在CT检查过程中的辐射照射通常利用自动剂量调制策略的基础上，较低的管电压结合迭代重建和其他剂量节省技术。碘化造影剂（CM）在低辐射剂量CT检查中可能发挥的重要作用尚不清楚。在此，我们讨论了碘化CM在低辐射剂量检查中的作用，并描述了优化CM给药方案的方法，以进一步降低辐射剂量和/或CM剂量，同时保持图像质量以进行准确诊断。类似于在低管电压设置下获得的较高碘衰减，高碘信号方案可以通过允许降低mAs同时保持信噪比来降低辐射剂量。这在首过检查中特别可行，其中可以通过更快速地注射碘来实现高碘信号。低kV和IR的组合也可用于降低碘剂量。在此，在最佳造影剂注射方案中，应减少CM给药剂量而不是碘浓度，因为使用高碘浓度CM可进一步减少现代首过检查的碘剂量。此外，较高浓度的CM更容易降低流速和体积，从而改善造影剂给药的耐受性。
Recent approaches to reducing radiation exposure during CT examinations typically utilize automated dose modulation strategies on the basis of lower tube voltage combined with iterative reconstruction and other dose-saving techniques. Less clearly appreciated is the potentially substantial role that iodinated contrast media (CM) can play in low-radiation-dose CT examinations. Herein we discuss the role of iodinated CM in low-radiation-dose examinations and describe approaches for the optimization of CM administration protocols to further reduce radiation dose and/or CM dose while maintaining image quality for accurate diagnosis. Similar to the higher iodine attenuation obtained at low-tube-voltage settings, high-iodine-signal protocols may permit radiation dose reduction by permitting a lowering of mAs while maintaining the signal-to-noise ratio. This is particularly feasible in first pass examinations where high iodine signal can be achieved by injecting iodine more rapidly. The combination of low kV and IR can also be used to reduce the iodine dose. Here, in optimum contrast injection protocols, the volume of CM administered rather than the iodine concentration should be reduced, since with high-iodine-concentration CM further reductions of iodine dose are achievable for modern first pass examinations. Moreover, higher concentrations of CM more readily allow reductions of both flow rate and volume, thereby improving the tolerability of contrast administration.
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影响因子：
--
作者：
Dorfman, Adam L.;Fazel, Reza;Einstein, Andrew J.;Applegate, Kimberly E.;Krumholz, Harlan M.;Wang, Yongfei;Christodoulou, Emmanuel;Chen, Jersey;Sanchez, Ramon;Nallamothu, Brahmajee K.
通讯作者：
Nallamothu, Brahmajee K.
DOI：
10.1056/nejmoa0901249
发表时间：
2009-08-27
期刊：
The New England journal of medicine
影响因子：
--
作者：
Fazel R;Krumholz HM;Wang Y;Ross JS;Chen J;Ting HH;Shah ND;Nasir K;Einstein AJ;Nallamothu BK
通讯作者：
Nallamothu BK
影响因子：
5.4
作者：
Andreini, Daniele;Pontone, Gianluca;Pepi, Mauro
通讯作者：
Pepi, Mauro
影响因子：
2.6
作者：
Bodelle, B.;Isler, S.;Beeres, M.
通讯作者：
Beeres, M.
影响因子：
6.7
作者：
Faggioni, Lorenzo;Gabelloni, Michela
通讯作者：
Gabelloni, Michela