Distribution of arterial lesions in Takayasu's arteritis and giant cell arteritis.
Distribution of arterial lesions in Takayasu's arteritis and giant cell arteritis.
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DOI：
10.1136/annrheumdis-2011-200795
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发表时间：
2012-08
影响因子：
27.4
通讯作者：
Vasculitis Clinical Research Consortium
中科院分区：
文献类型：
--
作者：
Grayson PC;Maksimowicz-McKinnon K;Clark TM;Tomasson G;Cuthbertson D;Carette S;Khalidi NA;Langford CA;Monach PA;Seo P;Warrington KJ;Ytterberg SR;Hoffman GS;Merkel PA;Vasculitis Clinical Research Consortium
目的比较高松动脉炎（Takayasu’s arteritis， TAK）和巨细胞动脉炎（giant cell arteritis， GCA）患者主动脉和初级分支的动脉造影病变模式。患者从两个北美的TAK和GCA队列中选择。计算15条大动脉的动脉造影病变频率。采用聚类分析得出TAK与GCA患者以及按发病年龄分类的患者的动脉疾病模式。利用潜在分类分析，将基于动脉疾病模式的计算机衍生分类模型与传统分类进行比较。145例TAK患者和62例GCA患者均有动脉造影病变。聚类分析表明，TAK和GCA的动脉受累在主动脉中是连续的，在成对的分支血管中通常是对称的。TAK组左侧颈动脉病变（p=0.03）和肠系膜病变（p=0.02）明显增多，GCA组左侧和右侧腋窝病变（p<0.01）明显增多。锁骨下疾病在TAK和发病年龄≤55岁的患者中呈不对称聚集，在GCA和发病年龄≤55岁的患者中呈对称聚集。计算机衍生的分类模型在两个亚组中区分了TAK和GCA，分别定义了26%和18%的研究样本；然而，56%的患者被分为一个亚组，在TAK和GCA之间没有明显的区别。在动脉病变的分布上，TAK和GCA有很强的相似性和细微的差异。这些发现表明，TAK和GCA可能存在于同一疾病的频谱上。
To compare patterns of arteriographic lesions of the aorta and primary branches in patients with Takayasu’s arteritis (TAK) and giant cell arteritis (GCA). Patients were selected from two North American cohorts of TAK and GCA. The frequency of arteriographic lesions was calculated for 15 large arteries. Cluster analysis was used to derive patterns of arterial disease in TAK versus GCA and in patients categorised by age at disease onset. Using latent class analysis, computer derived classification models based upon patterns of arterial disease were compared with traditional classification. Arteriographic lesions were identified in 145 patients with TAK and 62 patients with GCA. Cluster analysis demonstrated that arterial involvement was contiguous in the aorta and usually symmetric in paired branch vessels for TAK and GCA. There was significantly more left carotid (p=0.03) and mesenteric (p=0.02) artery disease in TAK and more left and right axillary (p<0.01) artery disease in GCA. Subclavian disease clustered asymmetrically in TAK and in patients ≤55 years at disease onset and clustered symmetrically in GCA and patients >55 years at disease onset. Computer derived classification models distinguished TAK from GCA in two subgroups, defining 26% and 18% of the study sample; however, 56% of patients were classified into a subgroup that did not strongly differentiate between TAK and GCA. Strong similarities and subtle differences in the distribution of arterial disease were observed between TAK and GCA. These findings suggest that TAK and GCA may exist on a spectrum within the same disease.
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影响因子：
2.8
作者：
Cid, Maria C.;Prieto-Gonzalez, Sergio;Garcia-Martinez, Ana
通讯作者：
Garcia-Martinez, Ana
影响因子：
--
作者：
Maksimowicz-McKinnon, Kathleen;Clark, Tiffany M.;Hoffman, Gary S.
通讯作者：
Hoffman, Gary S.
影响因子：
--
作者：
Nuenninghoff, DM;Hunder, GG;Matteson, EL
通讯作者：
Matteson, EL
DOI：
10.1002/art.23315
发表时间：
2008-03-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Garcia-Martinez, Ana;Hernandez-Rodriguez, Jose;Cid, Maria C.
通讯作者：
Cid, Maria C.
影响因子：
1.6
作者：
Maksimowicz-McKinnon, Kathleen;Clark, Tiffany M.;Hoffman, Gary S.
通讯作者：
Hoffman, Gary S.