Towards the sustainable discovery and development of new antibiotics.
Towards the sustainable discovery and development of new antibiotics.
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DOI：
10.1038/s41570-021-00313-1
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Müller R
中科院分区：
文献类型：
--
作者：
Miethke M;Pieroni M;Weber T;Brönstrup M;Hammann P;Halby L;Arimondo PB;Glaser P;Aigle B;Bode HB;Moreira R;Li Y;Luzhetskyy A;Medema MH;Pernodet JL;Stadler M;Tormo JR;Genilloud O;Truman AW;Weissman KJ;Takano E;Sabatini S;Stegmann E;Brötz-Oesterhelt H;Wohlleben W;Seemann M;Empting M;Hirsch AKH;Loretz B;Lehr CM;Titz A;Herrmann J;Jaeger T;Alt S;Hesterkamp T;Winterhalter M;Schiefer A;Pfarr K;Hoerauf A;Graz H;Graz M;Lindvall M;Ramurthy S;Karlén A;van Dongen M;Petkovic H;Keller A;Peyrane F;Donadio S;Fraisse L;Piddock LJV;Gilbert IH;Moser HE;Müller R
对新型抗菌剂的需求不断增长，以治疗由耐多药细菌病原体在全球传播造成的危及生命的感染，这与目前对其开发的投资水平形成了鲜明对比，特别是在天然产物衍生和合成小分子领域。全世界迫切需要显示创新化学和作用模式的新试剂，以应对抗菌素耐药性构成的公共健康威胁。在这里，我们的联盟提出了一份战略蓝图，以大幅提高我们发现和开发新抗生素的能力。我们提出了短期和长期解决方案，以克服研究和资金各部门最紧迫的限制，旨在弥合学术、工业和政治利益攸关方之间的差距，并联合跨学科专业知识，以便有效地为翻译管道提供燃料，造福子孙后代。抗菌素耐药性对公众健康的威胁越来越大，鼓励开发新的抗菌剂是解决这一问题的最重要途径之一。这篇路线图文章旨在将产业界、学术界和政界的合作伙伴聚集在一起，并提出应对这一挑战的短期和长期解决方案。
An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast to the current level of investment in their development, particularly in the fields of natural-product-derived and synthetic small molecules. New agents displaying innovative chemistry and modes of action are desperately needed worldwide to tackle the public health menace posed by antimicrobial resistance. Here, our consortium presents a strategic blueprint to substantially improve our ability to discover and develop new antibiotics. We propose both short-term and long-term solutions to overcome the most urgent limitations in the various sectors of research and funding, aiming to bridge the gap between academic, industrial and political stakeholders, and to unite interdisciplinary expertise in order to efficiently fuel the translational pipeline for the benefit of future generations. Antimicrobial resistance is an increasing threat to public health and encouraging the development of new antimicrobials is one of the most important ways to address the problem. This Roadmap article aims to bring together industrial, academic and political partners, and proposes both short-term and long-term solutions to this challenge.
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影响因子：
14.8
作者：
Arrowsmith CH;Audia JE;Austin C;Baell J;Bennett J;Blagg J;Bountra C;Brennan PE;Brown PJ;Bunnage ME;Buser-Doepner C;Campbell RM;Carter AJ;Cohen P;Copeland RA;Cravatt B;Dahlin JL;Dhanak D;Edwards AM;Frederiksen M;Frye SV;Gray N;Grimshaw CE;Hepworth D;Howe T;Huber KV;Jin J;Knapp S;Kotz JD;Kruger RG;Lowe D;Mader MM;Marsden B;Mueller-Fahrnow A;Müller S;O'Hagan RC;Overington JP;Owen DR;Rosenberg SH;Roth B;Ross R;Schapira M;Schreiber SL;Shoichet B;Sundström M;Superti-Furga G;Taunton J;Toledo-Sherman L;Walpole C;Walters MA;Willson TM;Workman P;Young RN;Zuercher WJ
通讯作者：
Zuercher WJ
影响因子：
15.8
作者：
Alirol E;Wi TE;Bala M;Bazzo ML;Chen XS;Deal C;Dillon JR;Kularatne R;Heim J;Hooft van Huijsduijnen R;Hook EW;Lahra MM;Lewis DA;Ndowa F;Shafer WM;Tayler L;Workowski K;Unemo M;Balasegaram M
通讯作者：
Balasegaram M
影响因子：
7.4
作者：
Bader, Chantal D.;Neuber, Markus;Mueller, Rolf
通讯作者：
Mueller, Rolf
DOI：
10.1016/j.ijantimicag.2020.105944
发表时间：
2020-04-01
影响因子：
10.8
作者：
Baron, Sophie Alexandra;Devaux, Christian;Rolain, Jean-Marc
通讯作者：
Rolain, Jean-Marc
影响因子：
9.5
作者：
Bagherian M;Sabeti E;Wang K;Sartor MA;Nikolovska-Coleska Z;Najarian K
通讯作者：
Najarian K