Glomerular filtration rate and the kinetics of 123I-metaiodobenzylguanidine
Glomerular filtration rate and the kinetics of 123I-metaiodobenzylguanidine
复制标题
肾小球滤过率和 123I-间碘苄基胍的动力学
DOI：
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
D. Ackery
中科院分区：
文献类型：
--
作者：
G. Blake;V. Lewington;M. Zivanovic;D. Ackery
我们最近报道的证据表明，钙拮抗剂硝苯地平可以改善恶性嗜铬细胞瘤患者131I-metaiodobenzylguanidine （131I-MIBG）的肿瘤潴留。在研究肿瘤MIBG动力学的药理修饰过程中，重要的是要明确区分药物对MIBG细胞保留的直接影响和继发影响，例如肾小球滤过率（GFR）的改变。为了提供硝苯地平对肿瘤MIBG动力学影响的数值模拟所需的基本动力学数据，我们研究了GFR对MIBG血浆和肾脏动力学的影响。我们研究了10例患者的123I-MIBG血浆曲线和MIBG肾血浆清除率，这些患者从没有嗜铬细胞瘤的生化或显像证据的受试者到广泛传播的转移性疾病的个体。采用99mTc-DTPA血浆清除率法测定GFR。在四个病例中，对口服硝苯地平的患者进行了重复研究。GFR与MIBG血浆浓度、MIBG肾血浆清除率及早期（0 ~ 5 min）肾排出MIBG有统计学意义。这些数据允许在注射后的最初几分钟内评估血浆积分，这是肿瘤动力学数值建模中重要的数量。GFR被发现对全身MIBG动力学有主要影响，但也有证据表明转移性肿瘤负荷的影响。
We have recently reported evidence that the calcium antagonist nifedipine can improve the tumour retention of 131I-metaiodobenzylguanidine (131I-MIBG) in patients with malignant phaeochromocytoma. During studies of the pharmacological modification of tumour MIBG kinetics, it is important to distinguish clearly between a direct effect on MIBG cellular retention by a pharmaceutical, and secondary effects due, for example, to a change in glomerular filtration rate (GFR). In order to provide the fundamental kinetic data required for the numerical modelling of the effect of nifedipine on tumour MIBG kinetics, we have investigated the influence of GFR on MIBG plasma and renal kinetics. The 123I-MIBG plasma curve and MIBG renal plasma clearance rate were studied in ten patients, ranging from subjects without biochemical or scintigraphic evidence of phaeochromocytoma to individuals with widely disseminated metastatic disease. GFR was measured using the 99mTc-DTPA plasma clearance method. In four cases, the studies were repeated with the patients taking oral nifedipine. Statistically significant correlations were found between GFR and the MIBG plasma concentration, MIBG renal plasma clearance rate and the early (0 to 5 min) renal excretion of MIBG. The data permit the evaluation of the plasma integral during the first few min following bolus injection, a quantity important in the numerical modelling of tumour kinetics. GFR was found to have a major influence on whole-body MIBG kinetics, but there was also evidence of the effect of the metastatic tumour burden.
恶性嗜铬细胞瘤的放射性药物治疗。
DOI：
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发表时间：
1984
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Sisson,JC;Shapiro,B;Beierwaltes,WH;Glowniak,JV;Nakajo,M;Mangner,TJ;Carey,JE;Swanson,DP;Copp,JE;Satterlee,WG
通讯作者：
Satterlee,WG
放射性碘苄胍用于肾上腺素能肿瘤的闪烁扫描定位和治疗。
影响因子：
4.9
作者：
McEwan,AJ;Shapiro,B;Sisson,JC;Beierwaltes,WH;Ackery,DM
通讯作者：
Ackery,DM
影响因子：
158.5
作者：
SISSON, JC;FRAGER, MS;THOMPSON, NW
通讯作者：
THOMPSON, NW