Targeting bacterial degradation machinery as an antibacterial strategy.
Targeting bacterial degradation machinery as an antibacterial strategy.
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DOI：
10.1042/bcj20230191
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发表时间：
2023-11-15
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
利用细胞的自然降解机制用于治疗目的是一个令人兴奋的研究领域，就细菌而言，它还处于起步阶段。在这里，我们回顾了目前针对ClpCP系统的策略，ClpCP系统是许多科学感兴趣的细菌物种生物学中必不可少的蛋白质水解降解复合物。策略包括使用天然产物抗生素或酰基沉积肽来启动ClpCP活性的上调或下调。我们还研究了最近对BacPROTACs的研究，通过劫持ClpCP机制来触发感兴趣的特定蛋白质的降解。这些战略是对抗抗菌素耐药性的重要新途径。
The exploitation of a cell's natural degradation machinery for therapeutic purposes is an exciting research area in its infancy with respect to bacteria. Here, we review current strategies targeting the ClpCP system, which is a proteolytic degradation complex essential in the biology of many bacterial species of scientific interest. Strategies include using natural product antibiotics or acyldepsipeptides to initiate the up- or down-regulation of ClpCP activity. We also examine exciting recent forays into BacPROTACs to trigger the degradation of specific proteins of interest through the hijacking of the ClpCP machinery. These strategies represent an important emerging avenue for combatting antimicrobial resistance.
影响因子：
4.5
作者：
Collins KM;Evans NJ;Torpey JH;Harris JM;Haynes BA;Camp AH;Isaacson RL
通讯作者：
Isaacson RL