Amygdala response to smoking-cessation messages mediates the effects of serotonin transporter gene variation on quitting.
Amygdala response to smoking-cessation messages mediates the effects of serotonin transporter gene variation on quitting.
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DOI：
10.1016/j.neuroimage.2011.12.064
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发表时间：
2012-03
期刊：
影响因子：
5.7
通讯作者：
Strecher, Victor J.
中科院分区：
文献类型：
--
作者：
Jasinska, Agnes J.;Chua, Hannah Faye;Ho, S. Shaun;Polk, Thad A.;Rozek, Laura S.;Strecher, Victor J.
杏仁核在检测情绪显著刺激和增强对情绪信息的记忆方面起着至关重要的作用。越来越多的证据也表明，杏仁核在成瘾中起着至关重要的作用，也许是通过加强充满情感的药物线索和寻求药物行为之间的联系。在目前的研究中，通过整合功能性磁共振成像（fMRI），遗传学和结果数据，从一大群吸烟者谁完成了戒烟干预，并试图戒烟，我们表明，杏仁核也在戒烟中发挥作用。具体来说，我们证明了杏仁核对戒烟信息的反应是戒烟者干预后戒烟结果的预测因子。我们进一步表明，杏仁核的反应是由5-羟色胺转运蛋白的遗传变异调制，并介导这种遗传变异对戒烟的影响。这些结果指出了与戒烟相关的基因-大脑-行为途径，并增加了我们对杏仁核在尼古丁成瘾中作用的理解。
The amygdala is critically involved in detecting emotionally salient stimuli and in enhancing memory for emotional information. Growing evidence also suggests that the amygdala plays a crucial role in addiction, perhaps by strengthening associations between emotionally-charged drug cues and drug-seeking behavior. In the current study, by integrating functional MRI (fMRI), genetics, and outcome data from a large group of smokers who completed a smoking-cessation intervention and attempted to quit, we show that the amygdala also plays a role in quitting. Specifically, we demonstrate that the amygdala response to smoking-cessation messages in smokers trying to quit is a predictor of their post-intervention quitting outcome. We further show that the amygdala response is modulated by genetic variation in the serotonin transporter and mediates the impact of this genetic variation on quitting. These results point to a gene-brain-behavior pathway relevant to smoking cessation, and add to our understanding of the role of the amygdala in nicotine addiction.
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对量身定制的吸烟消息的自我相关的神经反应预测了戒烟。
影响因子：
25
作者：
Chua, Hannah Faye;Ho, S. Shaun;Jasinska, Agnes J.;Polk, Thad A.;Welsh, Robert C.;Liberzon, Israel;Strecher, Victor J.
通讯作者：
Strecher, Victor J.