Dietary linoleic acid and the ratio of unsaturated to saturated fatty acids are inversely associated with significant liver fibrosis risk: A nationwide survey.
Dietary linoleic acid and the ratio of unsaturated to saturated fatty acids are inversely associated with significant liver fibrosis risk: A nationwide survey.
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膳食亚油酸以及不饱和脂肪酸与饱和脂肪酸的比例与显着的肝纤维化风险呈负相关：一项全国性调查。
DOI：
10.3389/fnut.2022.938645
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发表时间：
2022
影响因子：
5
通讯作者：
Zhu, Hui-Lian
中科院分区：
文献类型：
--
作者：
Zhu, Tingting;Lu, Xiao-Ting;Liu, Zhao-Yan;Zhu, Hui-Lian
关键词：
由于没有药物被证明可以有效地减少肝纤维化，膳食脂肪酸在肝脏代谢中的重要作用可能是一种有益的非药物干预措施。在这项横断面研究中，我们分析了2017-2018年全国健康与营养检查调查周期的数据，以研究美国人群中膳食脂肪酸摄入比例和组成与显著肝纤维化之间的关系。根据两次24小时饮食回顾计算膳食脂肪酸摄入量。根据振动控制瞬时弹性成像得到的肝刚度测量值诊断肝纤维化。采用多变量logistic回归分析和敏感性分析来评估膳食脂肪酸摄入与显著肝纤维化风险之间的关系。最后，进行了限制性三次样条分析，以探讨多不饱和脂肪酸（PUFA）或亚油酸摄入量与显著肝纤维化风险之间的剂量反应。结果显示，与最低参考水平相比，不饱和脂肪酸与饱和脂肪酸比例、膳食PUFA和亚油酸摄入量最高水平的显著肝纤维化的多因素校正比值比（95%置信区间）分别为0.34（0.14-0.84）、0.68（0.50-0.91）和0.64（0.47-0.87）。敏感性分析和限制性三次样条分析得出了类似的结果，强调了不饱和脂肪酸与饱和脂肪酸的比例、多聚脂肪酸和亚油酸的消耗与显著的肝纤维化风险呈负相关。然而，其他膳食脂肪酸并没有显示出与肝纤维化显著相关的统计学意义。综上所述，饲粮中亚油酸可能在不饱和脂肪酸与饱和脂肪酸比例与肝纤维化风险呈负相关关系中发挥关键作用。需要进一步的研究来证实这些发现。
Since no pharmaceuticals have been proven to effectively reduce liver fibrosis, dietary fatty acids may be beneficial as one of the non-pharmaceutical interventions due to their important roles in liver metabolism. In this cross-sectional study, we analyzed the data from the 2017–2018 cycle of National Health and Nutrition Examination Survey to examine the associations between the proportion and composition of dietary fatty acid intakes with significant liver fibrosis among US population. The dietary fatty acid consumptions were calculated based on two 24-h dietary recalls. Significant liver fibrosis was diagnosed based on liver stiffness measurement value derived from the vibration controlled transient elastography. Multivariate logistic regression analysis and sensitivity analysis were performed to assess the association between dietary fatty acid consumption and significant liver fibrosis risk. Finally, restricted cubic spline analysis was carried out to explore the dose–response between polyunsaturated fatty acids (PUFA) or linoleic acid intakes and the risk of significant liver fibrosis. The results showed that the multivariate adjusted odds ratios (95% confidence intervals) of significant liver fibrosis were 0.34 (0.14–0.84), 0.68 (0.50–0.91), and 0.64 (0.47–0.87) for the highest level of unsaturated to saturated fatty acid ratio, dietary PUFA, and linoleic acid intakes compared to the lowest reference, respectively. The sensitivity analysis and restricted cubic spline analysis produced similar results, reinforcing the inverse association of unsaturated to saturated fatty acid ratio, PUFA, and linoleic acid consumptions with significant liver fibrosis risk. However, other dietary fatty acids did not show the statistically significant association with significant liver fibrosis. In conclusion, dietary linoleic acid may play a key role in the inverse association between the unsaturated to saturated fatty acid ratio and the risk of significant liver fibrosis. Further studies are needed to confirm these findings.
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影响因子：
7.1
作者：
Bjermo, Helena;Iggman, David;Riserus, Ulf
通讯作者：
Riserus, Ulf
影响因子：
13.5
作者：
Ioannou, George N.;Morrow, Olivia B.;Lee, Sum P.
通讯作者：
Lee, Sum P.
影响因子：
12.6
作者：
Kim, Donghee;Konyn, Peter;Ahmed, Aijaz
通讯作者：
Ahmed, Aijaz
影响因子：
5.9
作者：
de Almeida CF;da Silva PS;Cardoso CSA;Moreira NG;Antunes JC;de Andrade MM;Silva J;Araujo MC;Peres WAF;do Brasil PEAA;Moreira RI;Cardoso SW;Veloso VG;Grinsztejn B;de Brito PD;Perazzo H
通讯作者：
Perazzo H
影响因子：
29.4
作者：
Angulo P;Kleiner DE;Dam-Larsen S;Adams LA;Bjornsson ES;Charatcharoenwitthaya P;Mills PR;Keach JC;Lafferty HD;Stahler A;Haflidadottir S;Bendtsen F
通讯作者：
Bendtsen F