Neural substrates of parallel devaluation-sensitive and devaluation-insensitive Pavlovian learning in humans.
Neural substrates of parallel devaluation-sensitive and devaluation-insensitive Pavlovian learning in humans.
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DOI：
10.1038/s41467-023-43747-5
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发表时间：
2023-12-05
影响因子：
16.6
通讯作者：
O'Doherty, John P.
中科院分区：
文献类型：
--
作者：
Pool, Eva R.;Pauli, Wolfgang M.;Cross, Logan;O'Doherty, John P.
我们的目标是通过将学习任务与结果贬值，眼动追踪和功能磁共振成像相结合，区分对结果值变化敏感的巴甫洛夫关联的学习和编码所涉及的大脑区域。与理论预期相反，腹侧纹状体和扣带回中与奖励预测错误相关的体素似乎对贬值敏感。此外，区域编码状态预测误差似乎是贬值不敏感。我们还可以区分编码关于结果味道身份的预测的区域与关于预期空间位置的预测。编码对味觉身份的预测的区域似乎贬值敏感，而那些编码对结果的空间位置的预测似乎贬值不敏感。这些研究结果表明，在大脑中存在多种不同的联想机制，并帮助确定假定的神经相关的贬值敏感和不敏感的条件行为的平行表达。这项研究表明，参与人类巴甫洛夫学习的多个和不同的联想机制的证据，确定推定的神经相关的贬值敏感和不敏感的巴甫洛夫行为的平行表达。
We aim to differentiate the brain regions involved in the learning and encoding of Pavlovian associations sensitive to changes in outcome value from those that are not sensitive to such changes by combining a learning task with outcome devaluation, eye-tracking, and functional magnetic resonance imaging in humans. Contrary to theoretical expectation, voxels correlating with reward prediction errors in the ventral striatum and subgenual cingulate appear to be sensitive to devaluation. Moreover, regions encoding state prediction errors appear to be devaluation insensitive. We can also distinguish regions encoding predictions about outcome taste identity from predictions about expected spatial location. Regions encoding predictions about taste identity seem devaluation sensitive while those encoding predictions about an outcome’s spatial location seem devaluation insensitive. These findings suggest the existence of multiple and distinct associative mechanisms in the brain and help identify putative neural correlates for the parallel expression of both devaluation sensitive and insensitive conditioned behaviors. This study shows evidence for multiple and distinct associative mechanisms involved in human Pavlovian learning, identifying putative neural correlates for the parallel expression of both devaluation sensitive and insensitive Pavlovian behaviors.
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影响因子：
16.2
作者：
Boorman ED;Rajendran VG;O'Reilly JX;Behrens TE
通讯作者：
Behrens TE
基于模型和无模型的Pavlovian奖励学习：重估，修订和启示。
DOI：
10.3758/s13415-014-0277-8
发表时间：
2014-06
期刊：
Cognitive, affective & behavioral neuroscience
影响因子：
--
作者：
Dayan P;Berridge KC
通讯作者：
Berridge KC
影响因子：
16.2
作者：
Daw ND;Gershman SJ;Seymour B;Dayan P;Dolan RJ
通讯作者：
Dolan RJ
影响因子：
5.3
作者：
Battaglia, Simone;Garofalo, Sara;Starita, Francesca
通讯作者：
Starita, Francesca
影响因子：
5.7
作者：
Avants BB;Tustison NJ;Song G;Cook PA;Klein A;Gee JC
通讯作者：
Gee JC